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NCT03062878 · ClinicalTrials.gov registry record
The Effects of Anthracycline-based Chemotherapy on Peripheral Vascular Function
A clinical trial of Breast Cancer and Lymphoma, sponsored by Carl Ade, M.S., Ph.D..
- Completed
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT03062878 is a study of Breast Cancer and Lymphoma that has completed, run by Carl Ade, M.S., Ph.D.. The registered enrollment target is 60 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT03062878, a study of Breast Cancer and Lymphoma, has completed, sponsored by Carl Ade, M.S., Ph.D..
- COMPLETED
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall goal of this project is to determine the effects of anti-cancer chemotherapy on reflex control of blood pressure and vascular function. Recent data have demonstrated that cardiovascular disease-related mortality is the 2nd cause of morbidity and mortality for 7-year cancer survivors treated with chemotherapy. This anti-cancer treatment-mediated cardiotoxicity is a progressive process that begins at the molecular level, progresses to myocardial injury and left ventricular dysfunction, cumulating as heart failure and cardiovascular disease-related mortality. In parallel to these cardiac-specific changes, chemotherapy has also been shown to increase the risk for vascular-related abnormalities. However, the impact of adjuvant treatments on the function and structure of the peripheral vascular system remains poorly understood. With normal aging, two of the most important vascular adaptations to arteries, which strongly contribute to the increased risk of vascular-related and general cardiovascular disease, are an increase in large artery stiffness and dysfunction of the vascular endothelium. Therefore, the overall goal of this project is to determine the effects of anthracycline-based chemotherapy on large and small artery function and structure. The central hypothesis is that this type of cancer therapy results in negative vascular consequences as determined by non-invasive evaluation of spontaneous blood pressure control, carotid artery stiffness, and vascular endothelium-dependent vasodilation. This observational study is designed to increase our understanding of the vascular changes that occur during and following anti-cancer chemotherapy and provide insight into new methods that will decrease cardiovascular disease risk in those treated for cancer.
Conditions Studied
Interventions
- OTHER Arterial blood pressure
- OTHER Vascular Ultrasound
- OTHER Venous blood sample
- OTHER Skin microcirculatory blood flow
Study Locations (1)
Kansas
- Lafene Health Center - Manhattan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2017-02-01 |
| Est. Completion | 2018-08-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03062878
The ClinicalTrials.gov registry entry for NCT03062878 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (98% lower). The listed sponsor is Carl Ade, M.S., Ph.D., which has 2 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Breast Cancer appearing as the primary indexed condition, and to 4 interventions - of which Arterial blood pressure is the first listed.
NCT03062878 reports 1 study location spanning 1 distinct geographic area - top geographies include Kansas.
Frequently Asked Questions
What is clinical trial NCT03062878 about?
NCT03062878 is a clinical study titled "The Effects of Anthracycline-based Chemotherapy on Peripheral Vascular Function". The overall goal of this project is to determine the effects of anti-cancer chemotherapy on reflex control of blood pressure and vascular function. Recent data have demonstrated that cardiovascular disease-related mortality is the 2nd cause of morbidity and mortality for 7-year cancer survivors trea...
What is the current status of trial NCT03062878?
This trial is currently completed. The enrollment target is 60 participants. The study started on 2017-02-01. Estimated completion is 2018-08-01.
What conditions does trial NCT03062878 study?
This clinical trial studies the following conditions: Breast Cancer, Lymphoma, Chemotherapy Effect.
What interventions are being tested in trial NCT03062878?
The interventions under investigation include: Arterial blood pressure (OTHER), Vascular Ultrasound (OTHER), Venous blood sample (OTHER), Skin microcirculatory blood flow (OTHER).
Who is sponsoring clinical trial NCT03062878?
This trial is sponsored by Carl Ade, M.S., Ph.D., which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03062878 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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