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NCT03008915 · ClinicalTrials.gov registry record · Phase 2
Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency
A Phase 2 study, sponsored by Columbia University.
- Completed
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
NCT03008915: Completed Phase 2 study, sponsored by Columbia University.
NCT03008915 is a Phase 2 study that has completed, run by Columbia University. The registered enrollment target is 15 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03008915, a Phase 2 study, has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
Study Summary
The aim of this study is to test whether aspirin improves endothelial function in alpha-1 antitrypsin deficiency-associated lung disease, measured by pulmonary microvascular blood flow on magnetic resonance imaging (MRI) and with apoptotic endothelial microparticles.
Primary Outcome
Pulmonary microvascular blood flow is measured on contrast-enhanced MRI, limited to blood flow in the 2cm periphery of the lung
Interventions
- DRUG Placebo
- DRUG Aspirin
- OTHER Withdrawal from alpha1 antitrypsin replacement therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2017-01 |
| Est. Completion | 2020-10 |
| Phase | Phase 2 |
What the finished NCT03008915 record still lists
NCT03008915 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT03008915 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03008915 about?
NCT03008915 is a clinical study titled "Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency". The aim of this study is to test whether aspirin improves endothelial function in alpha-1 antitrypsin deficiency-associated lung disease, measured by pulmonary microvascular blood flow on magnetic resonance imaging (MRI) and with apoptotic endothelial microparticles.
What is the current status of trial NCT03008915?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 2017-01. Estimated completion is 2020-10.
What interventions are being tested in trial NCT03008915?
The interventions under investigation include: Placebo (DRUG), Aspirin (DRUG), Withdrawal from alpha1 antitrypsin replacement therapy (OTHER).
Who is sponsoring clinical trial NCT03008915?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03008915's enrollment target sits among peer trials
15 1919th of 2000 higher than 60 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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