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NCT02990078 · ClinicalTrials.gov registry record
Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury
A clinical trial, sponsored by University of Pennsylvania.
- Terminated
- Registry status
- 26
- Enrollment target
NCT02990078: Clinical Trial study, sponsored by University of Pennsylvania.
NCT02990078 is a clinical trial that was terminated before completion, run by University of Pennsylvania. The registered enrollment target is 26 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02990078 was terminated before completion, sponsored by University of Pennsylvania.
- TERMINATED
- Registry status
- 26 participants
- Enrollment target
Study Summary
The investigators will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (≤3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as compared to healthy controls. CVR will be measured by fNIRS response to hypercapnia. The investigators hypothesize that CVR will be decreased after TBI and that these decreases will correlate with clinical outcomes. Furthermore, the investigators predict that administration of a vasodilatory medication (sildenafil) will augment CVR after TBI.
Interventions
- DRUG Sildenafil citrate
- DEVICE Functional Near Infared Spectroscopy
- OTHER Hypercapnia Challenge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2016-12 |
| Est. Completion | 2022-09-30 |
Why NCT02990078 stopped before completion
NCT02990078 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 26 participants, a relatively small participant target.
The record links to 0 conditions, and to 3 interventions - of which Sildenafil citrate is the first listed.
NCT02990078 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02990078 about?
NCT02990078 is a clinical study titled "Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury". The investigators will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (≤3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as compared to healthy controls. CVR will be measured by fNIRS response to hyp...
What is the current status of trial NCT02990078?
This trial is currently terminated. The enrollment target is 26 participants. The study started on 2016-12. Estimated completion is 2022-09-30.
What interventions are being tested in trial NCT02990078?
The interventions under investigation include: Sildenafil citrate (DRUG), Functional Near Infared Spectroscopy (DEVICE), Hypercapnia Challenge (OTHER).
Who is sponsoring clinical trial NCT02990078?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
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