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ACTIVE NOT RECRUITING Phase 1

A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma

NCT02979522 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to assess the safety, tolerability, and anti-tumor activity, as well as confirm the recommended dose of brentuximab vedotin (ADCETRIS) in combination with a multiagent chemotherapy regimen, doxorubicin (Adriamycin), vinblastine, and dacarbazine, in pediatric participants with advanced stage newly diagnosed classical CD30+ Hodgkin Lymphoma (HL).

Conditions Studied

Interventions

  • DRUG Doxorubicin
  • DRUG Brentuximab vedotin
  • DRUG Dacarbazine
  • DRUG Vinblastine

Study Locations (14)

Other

  • Jardim das Americas — Paranã
  • INCA - Instituto Nacional de Cancer — Rio de Janeiro
  • GRAACC - Grupo de Apoio ao Adolescente e a Crianca com Cancer — São Paulo
  • ICr - Instituto da Crianca - HCFMUSP — São Paulo
  • Hospital Santa Marcelina — São Paulo
  • Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer — Florence
  • Fondazione IRCCS Policlinico San Matteo — Pavia
  • Ospedale Pediatrico Bambino Gesu,UOC Onco-ematologia — Roma
  • Azienda Ospedaliera Citta della Salute e della Scienza di Torino — Torino

Colorado

  • Children's Hospital Colorado — Aurora

Ohio

  • Cincinnati Children's Hospital Medical Center — Cincinnati

Estado de Bahia

  • Hospital Sao Rafael S/A — Salvador

Aichi-ken

  • NHO Nagoya Medical Center — Nagoya

Kanagawa

  • St. Marianna University School of Medicine Hospital — Kawasaki-shi

Trial Details

FieldValue
Enrollment Target 59 participants
Start Date 2017-09-06
Est. Completion 2029-09-24
Phase Phase 1

Sponsor

Takeda

387 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02979522

The ClinicalTrials.gov registry entry for NCT02979522 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Takeda, which has 387 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hodgkin Disease appearing as the primary indexed condition, and to 4 interventions — of which Doxorubicin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02979522 reports 14 study locations spanning 6 distinct geographic areas — top geographies include Other, Colorado, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02979522 about?

NCT02979522 is a clinical study titled "A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma". The purpose of this study is to assess the safety, tolerability, and anti-tumor activity, as well as confirm the recommended dose of brentuximab vedotin (ADCETRIS) in combination with a multiagent chemotherapy regimen, doxorubicin (Adriamycin), vinblastine, and dacarbazine, in pediatric participants...

What is the current status of trial NCT02979522?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 59 participants. The study started on 2017-09-06. Estimated completion is 2029-09-24.

What conditions does trial NCT02979522 study?

This clinical trial studies the following conditions: Hodgkin Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02979522?

The interventions under investigation include: Doxorubicin (DRUG), Brentuximab vedotin (DRUG), Dacarbazine (DRUG), Vinblastine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02979522?

This trial is sponsored by Takeda, which has 387 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02979522 being conducted?

This trial has 14 study locations across Colorado, Ohio, Estado de Bahia, Aichi-ken, Kanagawa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial