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NCT02977442 · ClinicalTrials.gov registry record · NA
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise
A NA study of Insulin Resistance, Diabetes, sponsored by Pennington Biomedical Research Center.
- Completed
- Registry status
- NA
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT02977442: Completed NA study of Insulin Resistance, Diabetes, sponsored by Pennington Biomedical Research Center.
NCT02977442 is a NA study of Insulin Resistance, Diabetes that has completed, run by Pennington Biomedical Research Center. The registered enrollment target is 24 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02977442, a NA study of Insulin Resistance, Diabetes, has completed, sponsored by Pennington Biomedical Research Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Insulin promotes the clearance of sugars from the blood into skeletal muscle and fat cells for use as energy; it also promotes storage of excess nutrients as fat. Type 2 diabetes occurs when the cells of the body become resistant to the effects of insulin, and this causes high blood sugar and contributes to a build-up of fat in muscle, pancreas, liver, and the heart. Understanding how insulin resistance occurs will pave the way for new therapies aimed at preventing and treating type 2 diabetes. Mitochondria are cellular structures that are responsible for turning nutrients from food, into the energy that our cells run on. As a result, mitochondria are known as "the powerhouse of the cell." Mitochondria are dynamic organelles that can move within a cell to the areas where they are needed, and can fuse together to form large, string-like, tubular networks or divide into small spherical structures. The name of this process is "mitochondrial dynamics" and the process keeps the cells healthy. However, when more food is consumed compared to the amount of energy burned, mitochondria may become overloaded and dysfunctional resulting in a leak of partially metabolized nutrients that can interfere with the ability of insulin to communicate within the cell. This may be a way for the cells to prevent further uptake of nutrients until the current supply has been exhausted. However, long term overload of the mitochondria may cause blood sugar levels to rise and lead to the development of type 2 diabetes. This study will provide information about the relationship between mitochondrial dynamics, insulin resistance and type 2 diabetes.
Primary Outcome
Dynamics will be assessed from quantitative measures of dynamin-related protein-1.
Conditions Studied
Interventions
- BEHAVIORAL exercise
Study Locations (1)
Louisiana
- Pennington Biomedical Research Center - Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2016-11 |
| Est. Completion | 2025-01 |
| Phase | NA |
What the finished NCT02977442 record still lists
NCT02977442 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Insulin Resistance, Diabetes appearing as the primary indexed condition, and to 1 intervention - of which exercise is the first listed.
NCT02977442 reports a single indexed study location in Louisiana.
Frequently Asked Questions
What is clinical trial NCT02977442 about?
NCT02977442 is a clinical study titled "Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise". Insulin promotes the clearance of sugars from the blood into skeletal muscle and fat cells for use as energy; it also promotes storage of excess nutrients as fat. Type 2 diabetes occurs when the cells of the body become resistant to the effects of insulin, and this causes high blood sugar and contri...
What is the current status of trial NCT02977442?
This trial is currently completed. It is a NA study. The enrollment target is 24 participants. The study started on 2016-11. Estimated completion is 2025-01.
What conditions does trial NCT02977442 study?
This clinical trial studies the following conditions: Insulin Resistance, Diabetes.
What interventions are being tested in trial NCT02977442?
The interventions under investigation include: exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT02977442?
This trial is sponsored by Pennington Biomedical Research Center, which has 258 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02977442 being conducted?
This trial has 1 study location across Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02977442's enrollment target sits among peer trials
24 1736th of 2000 higher than 246 of 2,000 other NA trials
participants (enrollment target), bucketed by value
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Source ClinicalTrials.gov registry export · 2026-08-08
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