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NCT02963025 · ClinicalTrials.gov registry record · NA
Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery
A NA study, sponsored by Technische Universität Dresden.
- Completed
- Registry status
- NA
- Development phase
- 2,200
- Enrollment target
NCT02963025: Completed NA study, sponsored by Technische Universität Dresden.
NCT02963025 is a NA study that has completed, run by Technische Universität Dresden. The registered enrollment target is 2,200 participants, above the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (57% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02963025, a NA study, has completed, sponsored by Technische Universität Dresden.
- COMPLETED
- Registry status
- NA
- Development phase
- 2,200 participants
- Enrollment target
Study Summary
One-lung ventilation (OLV) with resting of the contralateral lung may be required to allow or facilitate thoracic surgery. However, OLV can result in severe hypoxemia, requiring a mechanical ventilation approach that is able to maintain adequate gas exchange, while protecting the lungs against postoperative pulmonary complications (PPCs). During OLV, the use of lower tidal volumes is helpful to avoid over-distension, but can result in increased atelectasis and repetitive collapse-and-reopening of lung units, particularly at low levels of positive end-expiratory pressure (PEEP). Anesthesiologists inconsistently use PEEP and recruitment maneuvers (RM) in the hope that this may improve oxygenation and protect against PPC. Up to now, it is not known whether high levels of PEEP combined with RM are superior to lower PEEP without RM for protection against PPCs during OLV. Hypothesis: An intra-operative ventilation strategy using higher levels of PEEP and recruitment maneuvers, as compared to ventilation with lower levels of PEEP without recruitment maneuvers, prevents postoperative pulmonary complications in patients undergoing thoracic surgery under standardized one-lung ventilation.
Interventions
- PROCEDURE PEEP level
- PROCEDURE Use of recruitment maneuvers
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,200 participants |
| Start Date | 2017-01 |
| Est. Completion | 2024-08 |
| Phase | NA |
What the finished NCT02963025 record still lists
NCT02963025 is an interventional study that assigns participants to a tested intervention. Its 2,200 participants enrollment target places it among the larger protocols in the corpus, above the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (57% higher).
The record links to 0 conditions, and to 2 interventions - of which PEEP level is the first listed.
NCT02963025 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02963025 about?
NCT02963025 is a clinical study titled "Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery". One-lung ventilation (OLV) with resting of the contralateral lung may be required to allow or facilitate thoracic surgery. However, OLV can result in severe hypoxemia, requiring a mechanical ventilation approach that is able to maintain adequate gas exchange, while protecting the lungs against posto...
What is the current status of trial NCT02963025?
This trial is currently completed. It is a NA study. The enrollment target is 2,200 participants. The study started on 2017-01. Estimated completion is 2024-08.
What interventions are being tested in trial NCT02963025?
The interventions under investigation include: PEEP level (PROCEDURE), Use of recruitment maneuvers (PROCEDURE).
Who is sponsoring clinical trial NCT02963025?
This trial is sponsored by Technische Universität Dresden, which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02963025's enrollment target sits among peer trials
2,200 48th of 2000 higher than 1,952 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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