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NCT02963025 · ClinicalTrials.gov registry record · NA
Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery
A NA study, sponsored by Technische Universität Dresden.
- Completed
- Registry status
- NA
- Development phase
- 2,200
- Enrollment target
NCT02963025 is a NA study that has completed, run by Technische Universität Dresden. The registered enrollment target is 2,200 participants.
The verdict
NCT02963025, a NA study, has completed, sponsored by Technische Universität Dresden.
- COMPLETED
- Registry status
- NA
- Development phase
- 2,200 participants
- Enrollment target
Study Summary
One-lung ventilation (OLV) with resting of the contralateral lung may be required to allow or facilitate thoracic surgery. However, OLV can result in severe hypoxemia, requiring a mechanical ventilation approach that is able to maintain adequate gas exchange, while protecting the lungs against postoperative pulmonary complications (PPCs). During OLV, the use of lower tidal volumes is helpful to avoid over-distension, but can result in increased atelectasis and repetitive collapse-and-reopening of lung units, particularly at low levels of positive end-expiratory pressure (PEEP). Anesthesiologists inconsistently use PEEP and recruitment maneuvers (RM) in the hope that this may improve oxygenation and protect against PPC. Up to now, it is not known whether high levels of PEEP combined with RM are superior to lower PEEP without RM for protection against PPCs during OLV. Hypothesis: An intra-operative ventilation strategy using higher levels of PEEP and recruitment maneuvers, as compared to ventilation with lower levels of PEEP without recruitment maneuvers, prevents postoperative pulmonary complications in patients undergoing thoracic surgery under standardized one-lung ventilation.
Interventions
- PROCEDURE PEEP level
- PROCEDURE Use of recruitment maneuvers
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,200 participants |
| Start Date | 2017-01 |
| Est. Completion | 2024-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02963025
The ClinicalTrials.gov registry entry for NCT02963025 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 2,200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Technische Universität Dresden, which has 3 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which PEEP level is the first listed.
NCT02963025 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02963025 about?
NCT02963025 is a clinical study titled "Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery". One-lung ventilation (OLV) with resting of the contralateral lung may be required to allow or facilitate thoracic surgery. However, OLV can result in severe hypoxemia, requiring a mechanical ventilation approach that is able to maintain adequate gas exchange, while protecting the lungs against posto...
What is the current status of trial NCT02963025?
This trial is currently completed. It is a NA study. The enrollment target is 2,200 participants. The study started on 2017-01. Estimated completion is 2024-08.
What interventions are being tested in trial NCT02963025?
The interventions under investigation include: PEEP level (PROCEDURE), Use of recruitment maneuvers (PROCEDURE).
Who is sponsoring clinical trial NCT02963025?
This trial is sponsored by Technische Universität Dresden, which has 3 total clinical trials registered on ClinicalTrials.gov.
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