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Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir and Ribavirin in Participants With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie Clinical Study
NCT02939989 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study was to evaluate the efficacy and safety of co-administration of glecaprevir (ABT-493)/pibrentasvir (ABT 530) plus sofosbuvir (SOF) plus ribavirin (RBV) in hepatitis C virus (HCV) genotype (GT) 1 - 6-infected participants (including non-cirrhotic, or cirrhotic with compensated cirrhosis participants) who had experienced virologic failure in an AbbVie parent clinical study.
Conditions Studied
Interventions
- DRUG Ribavirin
- DRUG Sofosbuvir
- DRUG Glecaprevir/Pibrentasvir
Study Locations (20)
Other
- Beijing Di Tan Hospital, Capital Medical University /ID# 218496 — Beijing
- West China Hospital, Sichuan University /ID# 217613 — Chengdu
- The First Hospital Affiliated to AMU (Southwest Hospital) /ID# 218494 — Chongqing
- Mengchao Hepatobiliary Hospital of Fujian Medical University /ID# 218495 — Fuzhou
- Asklepios Klinik St. Georg /ID# 155733 — Hamburg
Alabama
- Digestive Health Specialists of the Southeast /ID# 155719 — Dothan
California
- Ruane Clinical Research Group /ID# 155714 — Los Angeles
Maryland
- Digestive Disease Associates - Baltimore /ID# 155713 — Baltimore
Michigan
- Henry Ford Health System /ID# 155720 — Detroit
New York
- University of Buffalo /ID# 155721 — Buffalo
North Carolina
- Carolinas Center For Liver Dis /ID# 155731 — Statesville
Tennessee
- Gastro One /ID# 155729 — Germantown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 33 participants |
| Start Date | 2016-11-21 |
| Est. Completion | 2021-07-30 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02939989
The ClinicalTrials.gov registry entry for NCT02939989 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 33 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie, which has 603 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Hepatitis C Virus Infection appearing as the primary indexed condition, and to 3 interventions — of which Ribavirin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02939989 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Other, Alabama, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02939989 about?
NCT02939989 is a clinical study titled "Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir and Ribavirin in Participants With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie Clinical Study". The purpose of this study was to evaluate the efficacy and safety of co-administration of glecaprevir (ABT-493)/pibrentasvir (ABT 530) plus sofosbuvir (SOF) plus ribavirin (RBV) in hepatitis C virus (HCV) genotype (GT) 1 - 6-infected participants (including non-cirrhotic, or cirrhotic with compensat...
What is the current status of trial NCT02939989?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 33 participants. The study started on 2016-11-21. Estimated completion is 2021-07-30.
What conditions does trial NCT02939989 study?
This clinical trial studies the following conditions: Hepatitis C Virus Infection. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02939989?
The interventions under investigation include: Ribavirin (DRUG), Sofosbuvir (DRUG), Glecaprevir/Pibrentasvir (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02939989?
This trial is sponsored by AbbVie, which has 603 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02939989 being conducted?
This trial has 20 study locations across Alabama, California, Maryland, Michigan, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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