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NCT02931110 · ClinicalTrials.gov registry record · Phase 1
Study of IV CBL0137 in Previously Treated Hematological Subjects
A Phase 1 study, sponsored by Incuron.
- Terminated
- Registry status
- Phase 1
- Development phase
- 5
- Enrollment target
NCT02931110: Clinical Trial Phase 1 study, sponsored by Incuron.
NCT02931110 is a Phase 1 study that was terminated before completion, run by Incuron. The registered enrollment target is 5 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02931110, a Phase 1 study, was terminated before completion, sponsored by Incuron.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
This clinical trial is a Phase 1, open-label, sequential-group, dose-escalation (Part 1) and cohort-expansion study (Part 2) evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of intravenously (IV) administered CBL0137 in participants with previously treated hematological malignancies.
Primary Outcome
MTD is defined as dose level at which ≥6 subjects have been treated and which is associated with a first-cycle dose-limiting toxicity (DLT) in ≤17% of the participants. RD may be the MTD or may be a lower dose within the tolerable dose range. Selection of the RD will be based on consideration of short- and long-term safety information together with available pharmacokinetic, pharmacodynamic, and efficacy data.
Interventions
- DRUG CBL0137
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2017-01 |
| Est. Completion | 2020-10 |
| Phase | Phase 1 |
Why NCT02931110 stopped before completion
NCT02931110 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 1 intervention - of which CBL0137 is the first listed.
NCT02931110 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02931110 about?
NCT02931110 is a clinical study titled "Study of IV CBL0137 in Previously Treated Hematological Subjects". This clinical trial is a Phase 1, open-label, sequential-group, dose-escalation (Part 1) and cohort-expansion study (Part 2) evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of intravenously (IV) administered CBL0137 in participants with previously treated hematologi...
What is the current status of trial NCT02931110?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 5 participants. The study started on 2017-01. Estimated completion is 2020-10.
What interventions are being tested in trial NCT02931110?
The interventions under investigation include: CBL0137 (DRUG).
Who is sponsoring clinical trial NCT02931110?
This trial is sponsored by Incuron, which has 2 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02931110's enrollment target sits among peer trials
5 1989th of 2000 higher than 6 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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