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NCT02874703 · ClinicalTrials.gov registry record
Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects
A clinical trial, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- 48
- Enrollment target
NCT02874703: Completed study, sponsored by Massachusetts General Hospital.
NCT02874703 is a clinical trial that has completed, run by Massachusetts General Hospital. The registered enrollment target is 48 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02874703 has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- 48 participants
- Enrollment target
Study Summary
In this study, investigators plan to test two potential mechanisms contributing to diastolic dysfunction among asymptomatic persons with HIV who are on cART. The first proposed mechanism is that heightened systemic immune activation/inflammation in HIV contributes to myocardial inflammation, which in turn promotes myocardial fibrosis. The second mechanism is that ectopic fat deposition (increased visceral adiposity) in HIV relates to increased intramyocardial lipid content, which in turn contributes to diastolic dysfunction. Both HIV positive and HIV-negative participants will undergo cardiac MRI/ MRS imaging studies for evaluation of myocardial fibrosis, myocardial inflammation, and intramyocardial lipid content. Traditional markers of CVD risk, inflammatory markers/immune, hormonal markers, and markers of myocardial stretch/injury will be assessed in relation to cardiac MRI/MRS outcomes. Additionally, a small subset of participants with HIV will undergo longitudinal evaluations to assess effects of a clinically prescribed hormonal therapy on myocardial structure and function.
Interventions
- OTHER Cardiac MRI/MRS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2016-08 |
| Est. Completion | 2019-08 |
What the finished NCT02874703 record still lists
NCT02874703 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 48 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Cardiac MRI/MRS is the first listed.
NCT02874703 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02874703 about?
NCT02874703 is a clinical study titled "Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects". In this study, investigators plan to test two potential mechanisms contributing to diastolic dysfunction among asymptomatic persons with HIV who are on cART. The first proposed mechanism is that heightened systemic immune activation/inflammation in HIV contributes to myocardial inflammation, which i...
What is the current status of trial NCT02874703?
This trial is currently completed. The enrollment target is 48 participants. The study started on 2016-08. Estimated completion is 2019-08.
What interventions are being tested in trial NCT02874703?
The interventions under investigation include: Cardiac MRI/MRS (OTHER).
Who is sponsoring clinical trial NCT02874703?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
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