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NCT02864329 · ClinicalTrials.gov registry record
Small RNA Pathways in Mammalian Gametogenesis
A clinical trial of Male Infertility, sponsored by Weill Medical College of Cornell University.
- Completed
- Registry status
- 182
- Enrollment target
- 1
- Study location
NCT02864329: Completed study of Male Infertility, sponsored by Weill Medical College of Cornell University.
NCT02864329 is a study of Male Infertility that has completed, run by Weill Medical College of Cornell University. The registered enrollment target is 182 participants, below the 535-participant average among 8 other Male Infertility trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02864329, a study of Male Infertility, has completed, sponsored by Weill Medical College of Cornell University.
- COMPLETED
- Registry status
- 182 participants
- Enrollment target
- 1
- Study location
Study Summary
Basic and clinical research is revealing that various noncoding and small RNAs play important and diverse roles in germ cell development and quality, including X/Y silencing during meiosis, gene regulation, DNA damage responses, and protection of the genome against transposable elements. Indeed, mammalian germ cells are known to harbor multiple small RNA species, including small interfering RNAs (siRNA), microRNAs (miRNA), and germline- specific PIWI- interacting RNAs (piRNA). However, their mechanistic roles in gametogenesis and human infertility are largely uncharacterized. The goal of this study is to elucidate the role of small RNA pathways in the events that give rise to viable euploid gametes. Four projects and three cores are included in this study.
Primary Outcome
Detect target mRNAs through correlation analysis of actual mRNA expression profiles obtained from the same patients. At the end of the proposed funding period, project 2 will have identified and confirmed a set of approximately 20-30 miRNA:mRNA interactions in male infertility.
Conditions Studied
Study Locations (1)
New York
- Weill Cornell Medicine - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 182 participants |
| Start Date | 2014-04 |
| Est. Completion | 2024-03-20 |
What the finished NCT02864329 record still lists
NCT02864329 is an observational study that tracks outcomes without assigning an intervention. The registered 182 participants enrollment target is mid-sized for trials with a published cap, below the 535-participant average among 8 other Male Infertility trials with a reported enrollment target (66% lower).
The record links to 1 condition, with Male Infertility appearing as the primary indexed condition, and to 0 interventions.
NCT02864329 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT02864329 about?
NCT02864329 is a clinical study titled "Small RNA Pathways in Mammalian Gametogenesis". Basic and clinical research is revealing that various noncoding and small RNAs play important and diverse roles in germ cell development and quality, including X/Y silencing during meiosis, gene regulation, DNA damage responses, and protection of the genome against transposable elements. Indeed, mam...
What is the current status of trial NCT02864329?
This trial is currently completed. The enrollment target is 182 participants. The study started on 2014-04. Estimated completion is 2024-03-20.
What conditions does trial NCT02864329 study?
This clinical trial studies the following conditions: Male Infertility.
Who is sponsoring clinical trial NCT02864329?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02864329 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02864329's enrollment target sits among peer trials
182 6th of 8 higher than 3 of 8 other Male Infertility trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Male Infertility trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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