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NCT02816138 · ClinicalTrials.gov registry record · Phase 4
Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study)
A Phase 4 study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 15
- Enrollment target
NCT02816138 is a Phase 4 study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 15 participants.
The verdict
NCT02816138, a Phase 4 study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 15 participants
- Enrollment target
Study Summary
Late-life depression is characterized by both affective (mood) symptoms and cognitive deficits. There is currently no intervention that may provide consistent benefits to both mood and cognitive performance. Agonist activity at the nicotinic acetylcholine receptors via transdermal nicotine patches may provide benefit to both mood and cognition, working through nicotine's effects on brain neural networks, specifically the cognitive control network and default mode network. In this initial pilot project, the investigators will test this hypotheses in 15 nonsmoking depressed elders with subjective cognitive impairment. Following baseline neuroimaging and cognitive testing, participants will receive 12 weeks of open-label transdermal nicotine. Afterwards, participants will repeat neuroimaging and cognitive assessments.
Interventions
- DRUG Nicotine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2016-10 |
| Est. Completion | 2017-09-12 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02816138
The ClinicalTrials.gov registry entry for NCT02816138 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Nicotine is the first listed.
NCT02816138 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02816138 about?
NCT02816138 is a clinical study titled "Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study)". Late-life depression is characterized by both affective (mood) symptoms and cognitive deficits. There is currently no intervention that may provide consistent benefits to both mood and cognitive performance. Agonist activity at the nicotinic acetylcholine receptors via transdermal nicotine patches m...
What is the current status of trial NCT02816138?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 15 participants. The study started on 2016-10. Estimated completion is 2017-09-12.
What interventions are being tested in trial NCT02816138?
The interventions under investigation include: Nicotine (DRUG).
Who is sponsoring clinical trial NCT02816138?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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