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NCT02791906 · ClinicalTrials.gov registry record · Phase 2
Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease
A Phase 2 study, sponsored by University of Pennsylvania.
- Terminated
- Registry status
- Phase 2
- Development phase
- 8
- Enrollment target
NCT02791906: Clinical Trial Phase 2 study, sponsored by University of Pennsylvania.
NCT02791906 is a Phase 2 study that was terminated before completion, run by University of Pennsylvania. The registered enrollment target is 8 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02791906, a Phase 2 study, was terminated before completion, sponsored by University of Pennsylvania.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 8 participants
- Enrollment target
Study Summary
Heart failure (HF) is an epidemic and is a major burden on the US healthcare system. The most common cardiovascular endpoint is HF. Thus, novel interventions to prevent HF in chronic kidney disease (CKD) are highly desirable. This study will assess: the variability in the response to isosorbide mononitrate (ISMN) therapy; the degree of change in central hemodynamics and cardiac endpoints through analysis of changes in left ventricle (LV) mass, diffuse myocardial fibrosis, and myocardial systolic and diastolic function.
Primary Outcome
Variability seen in change in LV mass with ISMN administration measured with steady-state free precession cardiac MRI, outcomes reflect the change, in grams
Interventions
- DIETARY_SUPPLEMENT Vitamin C
- DRUG ISMN
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2016-05 |
| Est. Completion | 2019-03 |
| Phase | Phase 2 |
Why NCT02791906 stopped before completion
NCT02791906 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 2 interventions - of which Vitamin C is the first listed.
NCT02791906 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02791906 about?
NCT02791906 is a clinical study titled "Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease". Heart failure (HF) is an epidemic and is a major burden on the US healthcare system. The most common cardiovascular endpoint is HF. Thus, novel interventions to prevent HF in chronic kidney disease (CKD) are highly desirable. This study will assess: the variability in the response to isosorbide mono...
What is the current status of trial NCT02791906?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 8 participants. The study started on 2016-05. Estimated completion is 2019-03.
What interventions are being tested in trial NCT02791906?
The interventions under investigation include: Vitamin C (DIETARY_SUPPLEMENT), ISMN (DRUG).
Who is sponsoring clinical trial NCT02791906?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02791906's enrollment target sits among peer trials
8 1990th of 2000 higher than 5 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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