Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02781350 · ClinicalTrials.gov registry record · NA
Anti-inflammatory Effects of Fiber
A NA study, sponsored by University at Buffalo.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT02781350 is a NA study that has completed, run by University at Buffalo. The registered enrollment target is 20 participants.
The verdict
NCT02781350, a NA study, has completed, sponsored by University at Buffalo.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
The main objective of this research is to investigate the effect of addition of fiber on the high fat high carbohydrate (HFHC) meal induced inflammation and oxidative stress mechanisms at the molecular level in humans, in vivo. The investigators have previously shown that the intake of one HFHC meal leads to an increase in oxidative stress and inflammation. HFHC meal also induces an increase in the expression of suppressor of cytokine signaling- 3 (SOCS-3) in the mononuclear cells (MNC), which interferes with insulin signal transduction and contributes to the pathogenesis of insulin resistance. In contrast, an American heart association (AHA) meal rich in fruits and fiber does not induce these effects. These observations are important since HFHC meal not only induces oxidative stress and inflammation but also lays the foundations of a potentially greater insulin resistance through the induction of SOCS-3, TLR-4 and TLR-2.
Interventions
- OTHER HFHC meal
- DIETARY_SUPPLEMENT HFHC MEAL plus Fiber
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2010-11 |
| Est. Completion | 2013-05 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02781350
The ClinicalTrials.gov registry entry for NCT02781350 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University at Buffalo, which has 67 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which HFHC meal is the first listed.
NCT02781350 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02781350 about?
NCT02781350 is a clinical study titled "Anti-inflammatory Effects of Fiber". The main objective of this research is to investigate the effect of addition of fiber on the high fat high carbohydrate (HFHC) meal induced inflammation and oxidative stress mechanisms at the molecular level in humans, in vivo. The investigators have previously shown that the intake of one HFHC meal...
What is the current status of trial NCT02781350?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2010-11. Estimated completion is 2013-05.
What interventions are being tested in trial NCT02781350?
The interventions under investigation include: HFHC meal (OTHER), HFHC MEAL plus Fiber (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02781350?
This trial is sponsored by University at Buffalo, which has 67 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.