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NCT02781350 · ClinicalTrials.gov registry record · NA
Anti-inflammatory Effects of Fiber
A NA study, sponsored by University at Buffalo.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT02781350: Completed NA study, sponsored by University at Buffalo.
NCT02781350 is a NA study that has completed, run by University at Buffalo. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02781350, a NA study, has completed, sponsored by University at Buffalo.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
The main objective of this research is to investigate the effect of addition of fiber on the high fat high carbohydrate (HFHC) meal induced inflammation and oxidative stress mechanisms at the molecular level in humans, in vivo. The investigators have previously shown that the intake of one HFHC meal leads to an increase in oxidative stress and inflammation. HFHC meal also induces an increase in the expression of suppressor of cytokine signaling- 3 (SOCS-3) in the mononuclear cells (MNC), which interferes with insulin signal transduction and contributes to the pathogenesis of insulin resistance. In contrast, an American heart association (AHA) meal rich in fruits and fiber does not induce these effects. These observations are important since HFHC meal not only induces oxidative stress and inflammation but also lays the foundations of a potentially greater insulin resistance through the induction of SOCS-3, TLR-4 and TLR-2.
Primary Outcome
The investigators hypothesize that addition of fiber intake will suppress NF-kappa B after HFHC meal. Therefore, changes in NF-kappa B activity will be compared as percent change form baseline after HFHC meal with or without fiber in lean and obese subjects
Interventions
- OTHER HFHC meal
- DIETARY_SUPPLEMENT HFHC MEAL plus Fiber
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2010-11 |
| Est. Completion | 2013-05 |
| Phase | NA |
What the finished NCT02781350 record still lists
NCT02781350 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which HFHC meal is the first listed.
NCT02781350 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02781350 about?
NCT02781350 is a clinical study titled "Anti-inflammatory Effects of Fiber". The main objective of this research is to investigate the effect of addition of fiber on the high fat high carbohydrate (HFHC) meal induced inflammation and oxidative stress mechanisms at the molecular level in humans, in vivo. The investigators have previously shown that the intake of one HFHC meal...
What is the current status of trial NCT02781350?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2010-11. Estimated completion is 2013-05.
What interventions are being tested in trial NCT02781350?
The interventions under investigation include: HFHC meal (OTHER), HFHC MEAL plus Fiber (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02781350?
This trial is sponsored by University at Buffalo, which has 67 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02781350's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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