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NCT02774226 · ClinicalTrials.gov registry record · Phase 2
Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease
A Phase 2 study, sponsored by Augusta University.
- Completed
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
NCT02774226: Completed Phase 2 study, sponsored by Augusta University.
NCT02774226 is a Phase 2 study that has completed, run by Augusta University. The registered enrollment target is 15 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02774226, a Phase 2 study, has completed, sponsored by Augusta University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
Study Summary
Chronic obstructive pulmonary disease (COPD) affects up to 14 million people and is among the top five leading causes of death worldwide. Although COPD is a disease of the lungs, recent evidence indicates that COPD is associated with multiple systemic consequences including vascular endothelial dysfunction. Recently, it has been suggested that more patients with COPD die from cardiovascular disease and coronary heart disease than of direct pulmonary complications. Examination of the mechanisms that contribute to a reduction nitric oxide (NO) bioavailability resulting in vascular endothelial dysfunction in patients with COPD are important as endothelial dysfunction has been indicated to be an independent predictor of future atherosclerotic cardiovascular disease and events.
Primary Outcome
Brachial artery FMD induced by reactive hyperemia assessed vascular endothelial function at baseline and 12 weeks after treatment.
Interventions
- DRUG Tetrahydrobiopterin (BH4)
- DIETARY_SUPPLEMENT Antioxidant Cocktail
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2015-09 |
| Est. Completion | 2018-07-30 |
| Phase | Phase 2 |
What the finished NCT02774226 record still lists
NCT02774226 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 2 interventions - of which Tetrahydrobiopterin (BH4) is the first listed.
NCT02774226 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02774226 about?
NCT02774226 is a clinical study titled "Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease". Chronic obstructive pulmonary disease (COPD) affects up to 14 million people and is among the top five leading causes of death worldwide. Although COPD is a disease of the lungs, recent evidence indicates that COPD is associated with multiple systemic consequences including vascular endothelial dysf...
What is the current status of trial NCT02774226?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 2015-09. Estimated completion is 2018-07-30.
What interventions are being tested in trial NCT02774226?
The interventions under investigation include: Tetrahydrobiopterin (BH4) (DRUG), Antioxidant Cocktail (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02774226?
This trial is sponsored by Augusta University, which has 106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02774226's enrollment target sits among peer trials
15 1919th of 2000 higher than 60 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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