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NCT02770118 · ClinicalTrials.gov registry record · NA
Effects of Sleep Restriction on BAT Activation in Humans
A NA study, sponsored by Columbia University.
- Completed
- Registry status
- NA
- Development phase
- 4
- Enrollment target
NCT02770118 is a NA study that has completed, run by Columbia University. The registered enrollment target is 4 participants.
The verdict
NCT02770118, a NA study, has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- NA
- Development phase
- 4 participants
- Enrollment target
Study Summary
The goal of this proposed research is to test the hypothesis that long-term mild sleep restriction (SR), as occurs frequently in adults and adolescents, leads to a positive energy balance and weight gain. Aim 1. To determine the effects of SR, relative to habitual sleep (HS), on food choice and energy intake (EI) in adults at risk of obesity. * Hypothesis 1a. EI, assessed by multiple weekly 24-hour recalls, will be greater during a period of SR relative to HS. This will be mostly due to increased fat and carbohydrate intakes. * Hypothesis 1b. Neuronal responses to food stimuli, assessed by functional MRI (fMRI) after 6 weeks of SR or HS, will indicate increased activity in networks associated with reward and food valuation (insula, orbitofrontal cortex) during a period of SR relative to HS. These responses will be correlated with intakes of high carbohydrate and high fat foods (hypothesis 1a) and neuropeptide Y (NPY). Moreover, activation of the default mode network (DMN) will be suppressed to a lesser extent after SR compared to HS. Aim 2. To determine the effects of SR, relative to HS, on energy expenditure (EE) via independent and complementary approaches. * Hypothesis 2a. EE, assessed by doubly-labeled water (DLW), and physical activity level, monitored daily by actigraphy, will be lower during SR relative to HS. * Hypothesis 2b. Brown adipose tissue (BAT), assessed by positron emission tomography and magnetic resonance combined scanner (PET/MR) using 18F-fluorodeoxyglucose (18FDG-PET) and fat fraction (FF) measurement under cold stimulation, will be greater after SR relative to HS. This would suggest higher adaptive thermogenesis after SR compared to HS. BAT activation will also be correlated with NPY. Aim 3. To determine whether SR alters body weight and adiposity relative to HS. * Hypothesis 3a. SR will lead to weight gain and increased total adiposity, as assessed using magnetic resonance imaging (MRI), relative to HS. * Hypothesis 3b. Increased adipos
Interventions
- BEHAVIORAL Partial Sleep Restriction
- BEHAVIORAL Total Sleep Deprivation
- BEHAVIORAL Habitual Sleep
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2016-01 |
| Est. Completion | 2017-07 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02770118
The ClinicalTrials.gov registry entry for NCT02770118 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 4 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Columbia University, which has 958 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Partial Sleep Restriction is the first listed.
NCT02770118 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02770118 about?
NCT02770118 is a clinical study titled "Effects of Sleep Restriction on BAT Activation in Humans". The goal of this proposed research is to test the hypothesis that long-term mild sleep restriction (SR), as occurs frequently in adults and adolescents, leads to a positive energy balance and weight gain. Aim 1. To determine the effects of SR, relative to habitual sleep (HS), on food choice and ene...
What is the current status of trial NCT02770118?
This trial is currently completed. It is a NA study. The enrollment target is 4 participants. The study started on 2016-01. Estimated completion is 2017-07.
What interventions are being tested in trial NCT02770118?
The interventions under investigation include: Partial Sleep Restriction (BEHAVIORAL), Total Sleep Deprivation (BEHAVIORAL), Habitual Sleep (BEHAVIORAL).
Who is sponsoring clinical trial NCT02770118?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
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