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NCT02769000 · ClinicalTrials.gov registry record · NA
Low Dose RT to Reduce Cerebral Amyloidosis in Early Alzheimer's
A NA study, sponsored by Virginia Commonwealth University.
- Terminated
- Registry status
- NA
- Development phase
- 5
- Enrollment target
NCT02769000: Clinical Trial NA study, sponsored by Virginia Commonwealth University.
NCT02769000 is a NA study that was terminated before completion, run by Virginia Commonwealth University. The registered enrollment target is 5 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02769000, a NA study, was terminated before completion, sponsored by Virginia Commonwealth University.
- TERMINATED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
Study Summary
Evaluate safety and toxicity/adverse events associated with delivery of low dose whole brain irradiation in patients with early Alzheimer's dementia according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria.. As a secondary goal it will establish whether or not the intervention with low dose whole brain irradiation stabilizes or decreases cerebral amyloid deposits and whether these correlate with the recognized progression of Alzheimer's dementia. The investigators will also collect information from the FDG and Amyvid® PET Scans to determine if there is any correlation between neurocognitive/quality of life scores and changes in amyloid plaque size, number and location.
Primary Outcome
Evaluate the toxicity associated with the delivery of low dose fractionated whole brain irradiation in subjects with early Alzheimer's dementia using the CTCAE toxicity grading system. The scale is 0 - 5 with 0 being no toxicity and 5 being fatal.
Interventions
- RADIATION 10 GY in 5 daily fractions
- RADIATION 20 GY in 10 daily fractions
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2016-05 |
| Est. Completion | 2019-03-15 |
| Phase | NA |
Why NCT02769000 stopped before completion
NCT02769000 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which 10 GY in 5 daily fractions is the first listed.
NCT02769000 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02769000 about?
NCT02769000 is a clinical study titled "Low Dose RT to Reduce Cerebral Amyloidosis in Early Alzheimer's". Evaluate safety and toxicity/adverse events associated with delivery of low dose whole brain irradiation in patients with early Alzheimer's dementia according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Associatio...
What is the current status of trial NCT02769000?
This trial is currently terminated. It is a NA study. The enrollment target is 5 participants. The study started on 2016-05. Estimated completion is 2019-03-15.
What interventions are being tested in trial NCT02769000?
The interventions under investigation include: 10 GY in 5 daily fractions (RADIATION), 20 GY in 10 daily fractions (RADIATION).
Who is sponsoring clinical trial NCT02769000?
This trial is sponsored by Virginia Commonwealth University, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02769000's enrollment target sits among peer trials
5 1988th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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