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NCT02766959 · ClinicalTrials.gov registry record
Allele-specific Expression of a Bitter Taste Receptor
A clinical trial, sponsored by Monell Chemical Senses Center.
- Completed
- Registry status
- 57
- Enrollment target
NCT02766959 is a clinical trial that has completed, run by Monell Chemical Senses Center. The registered enrollment target is 57 participants.
The verdict
NCT02766959 has completed, sponsored by Monell Chemical Senses Center.
- COMPLETED
- Registry status
- 57 participants
- Enrollment target
Study Summary
This single-site, within-subject experimental basic research study is designed to analyze the hypothesis that allele-specific expression of the bitter taste receptor T2R38 in taste tissue of individuals heterozygous for the taste receptor gene TAS2R38 correlates with that in nasal epithelium, and is responsible for differences in acyl-homoserine lactone-induced respiratory defenses. Subjects will include 100 predominantly European adults without chronic rhinosinusitis who will be undergoing a sinonasal procedure for reconstructive purposes. All subjects will provide saliva samples for genotyping, from which 25 subjects heterozygous for TAS2R38 (AVI/PAV) will be identified. These individuals will be asked to complete a beverage frequency questionnaire and taste test prior to the procedure that will evaluate for a number of compounds, among them bitter ligands specific to T2R38. Their tongue will also be photographed to evaluate the anatomy of their fungiform papillae, the mushroom-like structures on the tongue which contain taste buds. Subjects will subsequently provide nasal epithelium and taste tissue, which will be processed to 1) evaluate for allele-specific expression of TAS2R38 mRNA in both the taste and nasal tissue, with the nasal tissue concurrently being cultured in an air-liquid interface system to 2) assess the AHL-induced respiratory defenses of ciliary beat frequency (CBF) and nitric oxide (NO) production. Should subjects require a subsequent sinonasal procedure for clinically-determined reasons, taste and nasal tissue will again be obtained and analyzed for TAS2R38 mRNA, allowing for 3) longitudinal evaluation of mRNA expression level.
Interventions
- OTHER Observational study
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 57 participants |
| Start Date | 2016-01 |
| Est. Completion | 2018-08 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02766959
The ClinicalTrials.gov registry entry for NCT02766959 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 57 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Monell Chemical Senses Center, which has 16 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Observational study is the first listed.
NCT02766959 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02766959 about?
NCT02766959 is a clinical study titled "Allele-specific Expression of a Bitter Taste Receptor". This single-site, within-subject experimental basic research study is designed to analyze the hypothesis that allele-specific expression of the bitter taste receptor T2R38 in taste tissue of individuals heterozygous for the taste receptor gene TAS2R38 correlates with that in nasal epithelium, and is...
What is the current status of trial NCT02766959?
This trial is currently completed. The enrollment target is 57 participants. The study started on 2016-01. Estimated completion is 2018-08.
What interventions are being tested in trial NCT02766959?
The interventions under investigation include: Observational study (OTHER).
Who is sponsoring clinical trial NCT02766959?
This trial is sponsored by Monell Chemical Senses Center, which has 16 total clinical trials registered on ClinicalTrials.gov.
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