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NCT02750423 · ClinicalTrials.gov registry record · NA
Neurologic Injury Following Aortic Arch Replacement
A NA study of Aortic Arch Replacement and Hemi Arch Replacement, sponsored by Emory University.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 2
- Study locations
NCT02750423: Completed NA study of Aortic Arch Replacement and Hemi Arch Replacement, sponsored by Emory University.
NCT02750423 is a NA study of Aortic Arch Replacement and Hemi Arch Replacement that has completed, run by Emory University. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02750423, a NA study of Aortic Arch Replacement and Hemi Arch Replacement, has completed, sponsored by Emory University.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 2
- Study locations
Study Summary
Investigators are seeking to learn how well different cooling temperatures along with different blood flow pathways to the brain reduce the risk of injury to the brain in participants planning to undergo elective aortic arch and hemiarch surgery. Participants will be randomized to receive a cerebral protection strategy of either: deep hypothermic circulatory arrest and retrograde cerebral perfusion (DHCA+RCP) or moderate hypothermic circulatory arrest and unilateral selective antegrade cerebral perfusion (MHCA+uSACP). Evidence of neurologic injury will be assessed with neurologic exams, neurocognitive tests, MRI imaging of the brain and measurement of plasma S-100 levels during post operative follow ups.
Primary Outcome
The number of participants with a new focal neurologic deficit lasting greater than 24 hours that is confirmed by radiographic evidence of infarction.
Conditions Studied
Interventions
- PROCEDURE DHCA+RCP
- PROCEDURE MHCA + SACP
Study Locations (2)
Georgia
- Emory University Hospital - Atlanta
- Emory Saint Joseph's Hospital - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2016-04 |
| Est. Completion | 2017-12 |
| Phase | NA |
What the finished NCT02750423 record still lists
NCT02750423 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Aortic Arch Replacement appearing as the primary indexed condition, and to 2 interventions - of which DHCA+RCP is the first listed.
NCT02750423 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT02750423 about?
NCT02750423 is a clinical study titled "Neurologic Injury Following Aortic Arch Replacement". Investigators are seeking to learn how well different cooling temperatures along with different blood flow pathways to the brain reduce the risk of injury to the brain in participants planning to undergo elective aortic arch and hemiarch surgery. Participants will be randomized to receive a cerebral...
What is the current status of trial NCT02750423?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2016-04. Estimated completion is 2017-12.
What conditions does trial NCT02750423 study?
This clinical trial studies the following conditions: Aortic Arch Replacement, Hemi Arch Replacement.
What interventions are being tested in trial NCT02750423?
The interventions under investigation include: DHCA+RCP (PROCEDURE), MHCA + SACP (PROCEDURE).
Who is sponsoring clinical trial NCT02750423?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02750423 being conducted?
This trial has 2 study locations across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02750423's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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