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NCT02735343 · ClinicalTrials.gov registry record · Phase 3
The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine
A Phase 3 study, sponsored by Mike O'Callaghan Military Hospital.
- Terminated
- Registry status
- Phase 3
- Development phase
- 5
- Enrollment target
NCT02735343: Clinical Trial Phase 3 study, sponsored by Mike O'Callaghan Military Hospital.
NCT02735343 is a Phase 3 study that was terminated before completion, run by Mike O'Callaghan Military Hospital. The registered enrollment target is 5 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02735343, a Phase 3 study, was terminated before completion, sponsored by Mike O'Callaghan Military Hospital.
- TERMINATED
- Registry status
- Phase 3
- Development phase
- 5 participants
- Enrollment target
Study Summary
Investigators are comparing Ketamine to prochlorperazinecompazine for benign headaches in the ED. Subjects will be randomized into 1 of 2 groups. Group 1 will receive standard treatment of prochlorperazinecompazine 10 mg IV along with diphenhydramine 25 mg IV. Group 2 (research arm) will receive Ketamine 0.3 mg/kg along with ondansetron 4 mg IV. Subjects will be seen at 15, 30, 45, and 60 minutes post-intervention to obtain Heart Rate, Blood Pressure, Headache severity, Nausea severity, Vomiting severity, Anxiety severity, and Restlessness severity. At 24-48 hours post intervention we will contact subjects and assess their pain and assess their satisfaction with their migraine pain management as part of this study. Subjects' participation will last up to 48 hours post headache.
Primary Outcome
Subjects marked a line on a Visual Analogue Scale rating from None to Severe. Study staff measured the mark in millimeters and converted to a scale from 0 to 100 possible points, with 100 being most severe.
Interventions
- DRUG Ketamine
- DRUG Compazine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2016-08 |
| Est. Completion | 2017-05 |
| Phase | Phase 3 |
Why NCT02735343 stopped before completion
NCT02735343 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Ketamine is the first listed.
NCT02735343 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02735343 about?
NCT02735343 is a clinical study titled "The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine". Investigators are comparing Ketamine to prochlorperazinecompazine for benign headaches in the ED. Subjects will be randomized into 1 of 2 groups. Group 1 will receive standard treatment of prochlorperazinecompazine 10 mg IV along with diphenhydramine 25 mg IV. Group 2 (research arm) will receive Ket...
What is the current status of trial NCT02735343?
This trial is currently terminated. It is a Phase 3 study. The enrollment target is 5 participants. The study started on 2016-08. Estimated completion is 2017-05.
What interventions are being tested in trial NCT02735343?
The interventions under investigation include: Ketamine (DRUG), Compazine (DRUG).
Who is sponsoring clinical trial NCT02735343?
This trial is sponsored by Mike O'Callaghan Military Hospital, which has 26 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02735343's enrollment target sits among peer trials
5 1997th of 2000 higher than 3 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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