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NCT02684071 · ClinicalTrials.gov registry record · Phase 2
Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors
A Phase 2 study, sponsored by Nicklaus Children's Hospital f/k/a Miami Children's Hospital.
- Terminated
- Registry status
- Phase 2
- Development phase
- 3
- Enrollment target
NCT02684071: Clinical Trial Phase 2 study, sponsored by Nicklaus Children's Hospital f/k/a Miami Children's Hospital.
NCT02684071 is a Phase 2 study that was terminated before completion, run by Nicklaus Children's Hospital f/k/a Miami Children's Hospital. The registered enrollment target is 3 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02684071, a Phase 2 study, was terminated before completion, sponsored by Nicklaus Children's Hospital f/k/a Miami Children's Hospital.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 3 participants
- Enrollment target
Study Summary
The purpose of this research study is to test an experimental treatment method for recurrent or progressive brain tumors in children aged from 0-22 years. The use of methotrexate and chemotherapy (topotecan and cyclophosphamide) is experimental in this study. This means that their use by themselves or together has not been approved by the U.S. Food and Drug Administration for this usage.
Primary Outcome
MRI response
Interventions
- DRUG cyclophosphamide
- DRUG topotecan
- DRUG Intra thecal methotrexate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2016-02 |
| Est. Completion | 2019-12-09 |
| Phase | Phase 2 |
Why NCT02684071 stopped before completion
NCT02684071 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 3 interventions - of which cyclophosphamide is the first listed.
NCT02684071 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02684071 about?
NCT02684071 is a clinical study titled "Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors". The purpose of this research study is to test an experimental treatment method for recurrent or progressive brain tumors in children aged from 0-22 years. The use of methotrexate and chemotherapy (topotecan and cyclophosphamide) is experimental in this study. This means that their use by themselves ...
What is the current status of trial NCT02684071?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 3 participants. The study started on 2016-02. Estimated completion is 2019-12-09.
What interventions are being tested in trial NCT02684071?
The interventions under investigation include: cyclophosphamide (DRUG), topotecan (DRUG), Intra thecal methotrexate (DRUG).
Who is sponsoring clinical trial NCT02684071?
This trial is sponsored by Nicklaus Children's Hospital f/k/a Miami Children's Hospital, which has 9 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02684071's enrollment target sits among peer trials
3 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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