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NCT02630472 · ClinicalTrials.gov registry record · Phase 1
Topical Irrigation Therapy for CRS
A Phase 1 study, sponsored by University of Pennsylvania.
- Terminated
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
NCT02630472: Clinical Trial Phase 1 study, sponsored by University of Pennsylvania.
NCT02630472 is a Phase 1 study that was terminated before completion, run by University of Pennsylvania. The registered enrollment target is 10 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02630472, a Phase 1 study, was terminated before completion, sponsored by University of Pennsylvania.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
Study Summary
The purpose of the study is to evaluate the physiologic response of quinine-saline irrigations for acute exacerbation of uncomplicated chronic rhinosinusitis following endoscopic sinus surgery. Subjects who have previously had functional endoscopic sinus surgery with acute exacerbation of chronic rhinosinusitis will be randomized to either a quinine-saline or saline-placebo arm. The investigators will measure baseline and follow-up clinical and quality-of-life outcomes for both arms, and then compare the groups at the end of the study period. The investigators' hypothesis is that the participants in the quinine sulfate arm will perform better on all measures as compared to the control arm.
Primary Outcome
Pre and post treatment endoscopically-obtained sinonasal microbiologic cultures.
Interventions
- DRUG Placebo
- DRUG Quinine Sulfate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2015-10 |
| Est. Completion | 2017-05-04 |
| Phase | Phase 1 |
Why NCT02630472 stopped before completion
NCT02630472 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02630472 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02630472 about?
NCT02630472 is a clinical study titled "Topical Irrigation Therapy for CRS". The purpose of the study is to evaluate the physiologic response of quinine-saline irrigations for acute exacerbation of uncomplicated chronic rhinosinusitis following endoscopic sinus surgery. Subjects who have previously had functional endoscopic sinus surgery with acute exacerbation of chronic rh...
What is the current status of trial NCT02630472?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2015-10. Estimated completion is 2017-05-04.
What interventions are being tested in trial NCT02630472?
The interventions under investigation include: Placebo (DRUG), Quinine Sulfate (DRUG).
Who is sponsoring clinical trial NCT02630472?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02630472's enrollment target sits among peer trials
10 1913th of 2000 higher than 46 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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