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NCT02624934 · ClinicalTrials.gov registry record
Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis
A clinical trial, sponsored by Bassett Healthcare.
- Completed
- Registry status
- 9
- Enrollment target
NCT02624934: Completed study, sponsored by Bassett Healthcare.
NCT02624934 is a clinical trial that has completed, run by Bassett Healthcare. The registered enrollment target is 9 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02624934 has completed, sponsored by Bassett Healthcare.
- COMPLETED
- Registry status
- 9 participants
- Enrollment target
Study Summary
Aortic stenosis is a major cause of morbidity around the world. Progressive aortic stenosis leads to cardiac hypertrophy as a compensatory response. A maladaptive response may lead to heart failure at varying degrees of severity of aortic stenosis in individual patients. The predicting factors for the occurrence of a maladaptive response are not well defined. Therefore current medical therapy for aortic stenosis is considered insufficient and may actually cause harm. The only effective therapy for severe, symptomatic aortic stenosis is aortic valve replacement. It has been found in an experimental study that Podocan determines the degree of cardiac hypertrophy in response to pressure overload via the Wnt-pathway. The possible prognostic role of secreted circulating Wnt modulators in aortic stenosis has also recently gained attention. This project will attempt to establish the prognostic role of circulatory Podocan and Wnt modulators for maladaptive left ventricular response to aortic stenosis. This may help identify patients at particular risk to develop left ventricular dysfunction with aortic stenosis and improve understanding of the mechanisms of left ventricular remodeling in aortic stenosis. Hence, this may also later act as an important background in finding more effective therapies to prevent or delay maladaptive left ventricular response in aortic stenosis.
Primary Outcome
All patients having a cardiac MRI have an IV line placed as normal procedure. When the line has been placed, prior to contrast infusion (if applicable)or other medication administration, blood samples will be collected to test for circulatory Podocan .
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2015-10 |
| Est. Completion | 2020-06 |
What the finished NCT02624934 record still lists
NCT02624934 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 9 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT02624934 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02624934 about?
NCT02624934 is a clinical study titled "Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis". Aortic stenosis is a major cause of morbidity around the world. Progressive aortic stenosis leads to cardiac hypertrophy as a compensatory response. A maladaptive response may lead to heart failure at varying degrees of severity of aortic stenosis in individual patients. The predicting factors for t...
What is the current status of trial NCT02624934?
This trial is currently completed. The enrollment target is 9 participants. The study started on 2015-10. Estimated completion is 2020-06.
Who is sponsoring clinical trial NCT02624934?
This trial is sponsored by Bassett Healthcare, which has 16 total clinical trials registered on ClinicalTrials.gov.
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