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NCT02579460 · ClinicalTrials.gov registry record · NA
Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition
A NA study, sponsored by Dallas VA Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT02579460: Completed NA study, sponsored by Dallas VA Medical Center.
NCT02579460 is a NA study that has completed, run by Dallas VA Medical Center. The registered enrollment target is 15 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02579460, a NA study, has completed, sponsored by Dallas VA Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
The purpose of this study is to elucidate mechanisms whereby oxidative stress induced by acute reflux esophagitis: 1) activates p38 to regulate proteins that control the G1/S cell cycle checkpoint, and 2) activates HIFs (hypoxia inducible factors) to cause autocrine VEGF (vascular endothelial growth factor) signaling that triggers the EMT (epithelial-mesenchymal-transition) program in Barrett's esophagus.
Primary Outcome
Inflammation of the esophageal mucosa will be measured at baseline, 7 days, and at 14 days. Esophageal mucosal inflammation will be measured using esophageal mucosal biopsy specimens, and histopatholgical grading. Mucosal infiltration with inflammatory cells (neutrophils, eosinophils, and lymphocytes) will be measured.
Interventions
- OTHER Cessation of Acid Suppressing Medications
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2015-11 |
| Est. Completion | 2017-11 |
| Phase | NA |
What the finished NCT02579460 record still lists
NCT02579460 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Cessation of Acid Suppressing Medications is the first listed.
NCT02579460 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02579460 about?
NCT02579460 is a clinical study titled "Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition". The purpose of this study is to elucidate mechanisms whereby oxidative stress induced by acute reflux esophagitis: 1) activates p38 to regulate proteins that control the G1/S cell cycle checkpoint, and 2) activates HIFs (hypoxia inducible factors) to cause autocrine VEGF (vascular endothelial growth...
What is the current status of trial NCT02579460?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2015-11. Estimated completion is 2017-11.
What interventions are being tested in trial NCT02579460?
The interventions under investigation include: Cessation of Acid Suppressing Medications (OTHER).
Who is sponsoring clinical trial NCT02579460?
This trial is sponsored by Dallas VA Medical Center, which has 20 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02579460's enrollment target sits among peer trials
15 1881st of 2000 higher than 92 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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