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NCT02566590 · ClinicalTrials.gov registry record · NA
Preventing the Loss of Muscle and Function in Hospitalized Older Adults
A NA study, sponsored by University of Utah.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT02566590 is a NA study that has completed, run by University of Utah. The registered enrollment target is 20 participants.
The verdict
NCT02566590, a NA study, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
One third of independent older adults over the age of 65y will be hospitalized for an acute medical illness, injury, or operative procedure. Unfortunately, 50% of these older adults will experience functional decline during their hospital stay from the amount of time they are physically inactive and in bed. Following discharge, the functional deficits can persist for months and in many instances never return to pre-hospitalization levels thus compounding morbidity, health care costs and dying. A classic consequence of short-term bed rest in older adults is the significant loss in skeletal muscle mass which underlies the accelerated leg strength deficits. The investigator has shown that an important mechanism of skeletal muscle loss is the inability of nutrients to stimulate a normal muscle protein synthesis response; a process highly regulated by the mammalian target of rapamycin signaling pathway (mTOR) and amino acid transporters. Day to day maintenance of force generating muscle tissue is dictated by anabolic stimulation from muscle contraction and essential amino acid ingestion. Therefore, anabolic interventions such as neuromuscular electrical stimulation (NMES) and high quality protein supplementation that contains a high proportion of essential amino acids (whey protein) may be promising approach to maintain leg muscle mass and strength in hospitalized older adults and prevent the long term consequences of repeated periods of short-term physical inactivity. The purpose of this study is to test in older adults if the combination of NMES and protein supplementation is capable of preserving muscle mass and strength and maintaining muscle nutrient anabolic sensitivity during bed rest. The investigators current hypotheses are that daily NMES and protein supplementation during 5-days of bed rest in older adults will: 1) preserve lower extremity muscle mass and strength and 2) maintain muscle nutrient anabolic sensitivity as measured by mTOR signaling and amino acid
Interventions
- DEVICE NMES
- DIETARY_SUPPLEMENT Protein
- DIETARY_SUPPLEMENT non-protein placebo supplement
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2015-01 |
| Est. Completion | 2016-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02566590
The ClinicalTrials.gov registry entry for NCT02566590 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Utah, which has 818 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which NMES is the first listed.
NCT02566590 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02566590 about?
NCT02566590 is a clinical study titled "Preventing the Loss of Muscle and Function in Hospitalized Older Adults". One third of independent older adults over the age of 65y will be hospitalized for an acute medical illness, injury, or operative procedure. Unfortunately, 50% of these older adults will experience functional decline during their hospital stay from the amount of time they are physically inactive and...
What is the current status of trial NCT02566590?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2015-01. Estimated completion is 2016-12.
What interventions are being tested in trial NCT02566590?
The interventions under investigation include: NMES (DEVICE), Protein (DIETARY_SUPPLEMENT), non-protein placebo supplement (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02566590?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
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