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NCT02552355 · ClinicalTrials.gov registry record · Phase 2
Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
A Phase 2 study, sponsored by Colorado State University.
- Completed
- Registry status
- Phase 2
- Development phase
- 56
- Enrollment target
NCT02552355: Completed Phase 2 study, sponsored by Colorado State University.
NCT02552355 is a Phase 2 study that has completed, run by Colorado State University. The registered enrollment target is 56 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (58% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02552355, a Phase 2 study, has completed, sponsored by Colorado State University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 56 participants
- Enrollment target
Study Summary
The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program. In addition, the investigators propose that this stimulatory effect of protein feeding will overcome the potential blunting effect of metformin on exercise responses. The investigators will investigate these outcomes over a 12-week exercise-training program in older adults with pre-diabetes with or without metformin treatment.
Primary Outcome
Oxygen consumption was assessed via high-resolution mitochondrial respirometry in permeabilized skeletal muscle. This outcome was assessed via 2 different protocols; Protocol 1 was a substrate-uncoupler-inhibitor titration (SUIT) and Protocol 2 was an adenosine diphosphate (ADP) titration. These data are reported as the percent change from baseline compared to 12 weeks.
Interventions
- DRUG Placebo
- DRUG Metformin
- DIETARY_SUPPLEMENT Carbohydrate Beverage
- DIETARY_SUPPLEMENT Protein Beverage
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2015-08 |
| Est. Completion | 2017-08 |
| Phase | Phase 2 |
What the finished NCT02552355 record still lists
NCT02552355 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 56 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (58% lower).
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT02552355 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02552355 about?
NCT02552355 is a clinical study titled "Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin". The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program. In addition, the investigators propose that this stimulatory effect of protein feeding will overcome the potential blunting effect...
What is the current status of trial NCT02552355?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 56 participants. The study started on 2015-08. Estimated completion is 2017-08.
What interventions are being tested in trial NCT02552355?
The interventions under investigation include: Placebo (DRUG), Metformin (DRUG), Carbohydrate Beverage (DIETARY_SUPPLEMENT), Protein Beverage (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02552355?
This trial is sponsored by Colorado State University, which has 94 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02552355's enrollment target sits among peer trials
56 1146th of 2000 higher than 848 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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