Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02471651 · ClinicalTrials.gov registry record · Phase 4
Dexamethasone Intravitreal Implant for the Treatment of Persistent Diabetic Macular Edema
A Phase 4 study, sponsored by California Retina Consultants.
- Completed
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
NCT02471651: Completed Phase 4 study, sponsored by California Retina Consultants.
NCT02471651 is a Phase 4 study that has completed, run by California Retina Consultants. The registered enrollment target is 40 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02471651, a Phase 4 study, has completed, sponsored by California Retina Consultants.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
Study Summary
Laser photocoagulation and intravitreal anti-vascular growth factor injections are commonly used treatment options for individuals with diabetic macular edema. However, some patients continue to experience persistent diabetic macular edema and poor vision despite continued laser and/or anti-vegf therapy. Recent clinical trials suggest that due to inflammatory mediators dexamethasone intravitreal implant (0.7mg) may be a good alternative therapy for individuals unresponsive to laser photocoagulation or intravitreal anti-vascular growth factor injections. The purpose of this research study is to compare the effectiveness of using a dexamethasone steroid implant versus monthly intravitreal anti-VEGF injections for research participants with persistent diabetic macular edema (DME).
Primary Outcome
Mean change in central 1 mm sub-field thickness between baseline and 9 months as measured by Spectral Domain Optical Coherence Tomography (SDOCT).
Interventions
- DRUG Dexamethasone intravitreal implant (0.7 mg)
- DRUG Intravitreal anti-VEGF injection
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2015-06 |
| Est. Completion | 2018-10-24 |
| Phase | Phase 4 |
What the finished NCT02471651 record still lists
NCT02471651 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 2 interventions - of which Dexamethasone intravitreal implant (0.7 mg) is the first listed.
NCT02471651 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02471651 about?
NCT02471651 is a clinical study titled "Dexamethasone Intravitreal Implant for the Treatment of Persistent Diabetic Macular Edema". Laser photocoagulation and intravitreal anti-vascular growth factor injections are commonly used treatment options for individuals with diabetic macular edema. However, some patients continue to experience persistent diabetic macular edema and poor vision despite continued laser and/or anti-vegf the...
What is the current status of trial NCT02471651?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2015-06. Estimated completion is 2018-10-24.
What interventions are being tested in trial NCT02471651?
The interventions under investigation include: Dexamethasone intravitreal implant (0.7 mg) (DRUG), Intravitreal anti-VEGF injection (DRUG).
Who is sponsoring clinical trial NCT02471651?
This trial is sponsored by California Retina Consultants, which has 8 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02471651's enrollment target sits among peer trials
40 1397th of 2000 higher than 533 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia