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NCT02449369 · ClinicalTrials.gov registry record · Phase 4
Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
A Phase 4 study, sponsored by AdventHealth.
- Completed
- Registry status
- Phase 4
- Development phase
- 180
- Enrollment target
NCT02449369: Completed Phase 4 study, sponsored by AdventHealth.
NCT02449369 is a Phase 4 study that has completed, run by AdventHealth. The registered enrollment target is 180 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (65% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02449369, a Phase 4 study, has completed, sponsored by AdventHealth.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 180 participants
- Enrollment target
Study Summary
This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces the need for opioid pain medication and reduces average pain scores.
Primary Outcome
verbal subjective assessment by patient reported to nursing at standard assessment times as an ordinal number between 0 and 10 (inclusive) where 0 is no pain and 10 is the maximum pain imaginable
Interventions
- DRUG Preop acetaminophen IV
- DRUG Preop orphenadrine IV
- DRUG Postop oral oxycodone & acetaminophen
- DRUG Postop hydromorphone IV
- DRUG Postop oral orphenadrine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2015-04 |
| Est. Completion | 2016-09 |
| Phase | Phase 4 |
What the finished NCT02449369 record still lists
NCT02449369 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (65% lower).
The record links to 0 conditions, and to 5 interventions - of which Preop acetaminophen IV is the first listed.
NCT02449369 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02449369 about?
NCT02449369 is a clinical study titled "Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee". This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces the need for opioid pain medication and reduces average pain scores.
What is the current status of trial NCT02449369?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 180 participants. The study started on 2015-04. Estimated completion is 2016-09.
What interventions are being tested in trial NCT02449369?
The interventions under investigation include: Preop acetaminophen IV (DRUG), Preop orphenadrine IV (DRUG), Postop oral oxycodone & acetaminophen (DRUG), Postop hydromorphone IV (DRUG), Postop oral orphenadrine (DRUG).
Who is sponsoring clinical trial NCT02449369?
This trial is sponsored by AdventHealth, which has 95 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02449369's enrollment target sits among peer trials
180 466th of 2000 higher than 1,525 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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