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NCT02411643 · ClinicalTrials.gov registry record · Early Phase 1
Molecular Effects of Topical Calcipotriene on Morphea
A Early Phase 1 study, sponsored by Northwestern University.
- Terminated
- Registry status
- Early Phase 1
- Development phase
- 2
- Enrollment target
NCT02411643: Clinical Trial Early Phase 1 study, sponsored by Northwestern University.
NCT02411643 is a Early Phase 1 study that was terminated before completion, run by Northwestern University. The registered enrollment target is 2 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02411643, a Early Phase 1 study, was terminated before completion, sponsored by Northwestern University.
- TERMINATED
- Registry status
- Early Phase 1
- Development phase
- 2 participants
- Enrollment target
Study Summary
This study will look into how topical treatment with synthetic Vitamin D3, calcipotriene ointment, used as standard of care, works in patients with morphea. Skin biopsies of morphea lesions before and after treatment with topical calcipotriene 0.005% ointment will be analyzed for changes in RNA and protein. A skin biopsy of unaffected skin will also be obtained and used for a control. This is an initial study to look at the molecular effects of topical calcipotriene on human morphea-involved skin. This study will look at the differences between affected and unaffected skin. This study also will look at clinical outcomes in morphea patients and determine if there are any clinical predictors for improvement with the medication.
Primary Outcome
Skin biopsy will be taken at day 0 and 3 months, RNA will be looked at for different gene expression levels
Interventions
- DRUG topical calcipotriene 0.005% ointment
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2015-03 |
| Est. Completion | 2016-04 |
| Phase | Early Phase 1 |
Why NCT02411643 stopped before completion
NCT02411643 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which topical calcipotriene 0.005% ointment is the first listed.
NCT02411643 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02411643 about?
NCT02411643 is a clinical study titled "Molecular Effects of Topical Calcipotriene on Morphea". This study will look into how topical treatment with synthetic Vitamin D3, calcipotriene ointment, used as standard of care, works in patients with morphea. Skin biopsies of morphea lesions before and after treatment with topical calcipotriene 0.005% ointment will be analyzed for changes in RNA and ...
What is the current status of trial NCT02411643?
This trial is currently terminated. It is a Early Phase 1 study. The enrollment target is 2 participants. The study started on 2015-03. Estimated completion is 2016-04.
What interventions are being tested in trial NCT02411643?
The interventions under investigation include: topical calcipotriene 0.005% ointment (DRUG).
Who is sponsoring clinical trial NCT02411643?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02411643's enrollment target sits among peer trials
2 1973rd of 2000 higher than 16 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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