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COMPLETED Phase 2

A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer

NCT02399137 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to determine whether the combination of MM-141 plus nab-paclitaxel and gemcitabine is more effective than nab-paclitaxel and gemcitabine alone based on Progression Free Survival (PFS) in front-line metastatic pancreatic cancer patients with high serum levels of free IGF-1.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Nab-Paclitaxel
  • DRUG Gemcitabine
  • DRUG MM-141

Study Locations (20)

California

  • Pacific Cancer Medical Center, Inc. — Anaheim
  • St. Jude Heritage Healthcare — Fullerton
  • UCLA School of Medicine — Los Angeles
  • Cancer Care Assoc Med Grp — Redondo Beach
  • UCSF Cancer Center — San Francisco
  • Sansum Clinic — Santa Barbara
  • Central Coast Med Onc Corp — Santa Maria

Illinois

  • Northwestern University — Chicago
  • University of Illinois at Chicago — Chicago
  • Illinois Cancer Specialists — Chicago
  • Oncology Specialists, S.C. — Park Ridge
  • Midwest Regional Medical Cntr — Zion

Florida

  • Baptist Health Med Gr Onc, LLC — Miami
  • Florida Cancer AffiliatesOcala — Ocala
  • Memorial Regional Hospital — Pembroke Pines

Arizona

  • Banner MD Anderson Cancer Ctr. — Gilbert

Colorado

  • Rocky Mountain Cancer Centers — Aurora

Georgia

  • Cancer Treatment Centers of America-Georgia — Newnan

Iowa

  • Nylen Cancer Center — Sioux City

Louisiana

  • Cancer Center of Acadiana Research Department — Lafayette

Trial Details

FieldValue
Enrollment Target 88 participants
Start Date 2015-05
Est. Completion 2018-08
Phase Phase 2

Sponsor

Merrimack Pharmaceuticals

5 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02399137

The ClinicalTrials.gov registry entry for NCT02399137 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 88 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merrimack Pharmaceuticals, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Pancreatic Cancer appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02399137 reports 20 study locations spanning 8 distinct geographic areas — top geographies include California, Illinois, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02399137 about?

NCT02399137 is a clinical study titled "A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer". The purpose of this study is to determine whether the combination of MM-141 plus nab-paclitaxel and gemcitabine is more effective than nab-paclitaxel and gemcitabine alone based on Progression Free Survival (PFS) in front-line metastatic pancreatic cancer patients with high serum levels of free IGF-...

What is the current status of trial NCT02399137?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 88 participants. The study started on 2015-05. Estimated completion is 2018-08.

What conditions does trial NCT02399137 study?

This clinical trial studies the following conditions: Pancreatic Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02399137?

The interventions under investigation include: Placebo (DRUG), Nab-Paclitaxel (DRUG), Gemcitabine (DRUG), MM-141 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02399137?

This trial is sponsored by Merrimack Pharmaceuticals, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02399137 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial