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NCT02352766 · ClinicalTrials.gov registry record
Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules
A clinical trial, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 256
- Enrollment target
NCT02352766: Completed study, sponsored by University of Pittsburgh.
NCT02352766 is a clinical trial that has completed, run by University of Pittsburgh. The registered enrollment target is 256 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02352766 has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 256 participants
- Enrollment target
Study Summary
Recently, targeted next generation sequencing (NGS) platforms have been introduced that allow inexpensive testing for hundreds of mutational hotspots at the same time. A number of additional mutational markers in thyroid cancer have been identified. Highly promising markers associated with tumor prognosis have also been found. This multi-institutional study aims to validate the diagnostic use of mutational markers in thyroid nodules with indeterminate cytology. The proposed hypothesis is that a broad NGS-based genotyping of thyroid nodules using a large panel of mutational markers applied to thyroid FNA samples can provide an accurate cancer risk stratification in thyroid nodules. The performance of the panel will be tested in a multi-institutional double-blind prospective study of FNA samples from thyroid nodules with indeterminate cytology and available surgical outcome
Primary Outcome
The primary outcome measured in this study is the performance (sensitivity, specificity, NPV, PPV) of the Thyroseq Panel in diagnosing cancer in thyroid nodules with Bethesda III, VI and V cytology.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 256 participants |
| Start Date | 2015-01 |
| Est. Completion | 2019-02-15 |
What the finished NCT02352766 record still lists
NCT02352766 is an observational study that tracks outcomes without assigning an intervention. The registered 256 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT02352766 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02352766 about?
NCT02352766 is a clinical study titled "Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules". Recently, targeted next generation sequencing (NGS) platforms have been introduced that allow inexpensive testing for hundreds of mutational hotspots at the same time. A number of additional mutational markers in thyroid cancer have been identified. Highly promising markers associated with tumor pro...
What is the current status of trial NCT02352766?
This trial is currently completed. The enrollment target is 256 participants. The study started on 2015-01. Estimated completion is 2019-02-15.
Who is sponsoring clinical trial NCT02352766?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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