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NCT02341326 · ClinicalTrials.gov registry record
Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD
A clinical trial, sponsored by Weill Medical College of Cornell University.
- Completed
- Registry status
- 111
- Enrollment target
NCT02341326: Completed study, sponsored by Weill Medical College of Cornell University.
NCT02341326 is a clinical trial that has completed, run by Weill Medical College of Cornell University. The registered enrollment target is 111 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02341326 has completed, sponsored by Weill Medical College of Cornell University.
- COMPLETED
- Registry status
- 111 participants
- Enrollment target
Study Summary
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation. Airway basal cells (BC) are stem/progenitor cells necessary for generation of differentiated airway epithelium. Based on our preliminary observations on SAE BC cells and FGFR2 signaling, we hypothesized that suppression of FGFR2 signaling in the SAE BC stem/progenitor cells by cigarette smoking renders these cells less potent in generating and maintaining normally differentiated SAE, shifting these cells towards a COPD associated phenotype. To test this, SAE basal cells will be isolated from cultured cells obtained through bronchoscopic brushings and analyzed through in vitro assays for their stem/progenitor capacities.
Primary Outcome
Measure of Expression of FGFR2 and related pathways in SAE BC
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 111 participants |
| Start Date | 2014-07 |
| Est. Completion | 2024-10-29 |
What the finished NCT02341326 record still lists
NCT02341326 is an observational study that tracks outcomes without assigning an intervention. The registered 111 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT02341326 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02341326 about?
NCT02341326 is a clinical study titled "Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD". Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation. Airway basal cells (BC) are stem/progenitor cells necessary for generation of diffe...
What is the current status of trial NCT02341326?
This trial is currently completed. The enrollment target is 111 participants. The study started on 2014-07. Estimated completion is 2024-10-29.
Who is sponsoring clinical trial NCT02341326?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
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