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NCT02296359 · ClinicalTrials.gov registry record
Vaccination Response in Individual Monozygotic Twins
A clinical trial, sponsored by Michigan State University.
- Terminated
- Registry status
- 1
- Enrollment target
NCT02296359 is a clinical trial that was terminated before completion, run by Michigan State University. The registered enrollment target is 1 participants.
The verdict
NCT02296359 was terminated before completion, sponsored by Michigan State University.
- TERMINATED
- Registry status
- 1 participants
- Enrollment target
Study Summary
Respiratory viruses are known to be risk factors for asthma (e.g respiratory syncytial viruses, RSVs, and Human Rhinoviruses, HRVs, may induce bronchiolitis, and wheezing illnesses respectively). The common flu is also known to be a risk factor and the Centers for Disease Control and Prevention (CDC) recommends that asthmatics receive the annual flu vaccine, as a high-risk group for related asthma exacerbations. The investigators will be evaluating the variation in individual responses over time after controlled immune activation following influenza vaccination of monozygotic twins, both discordant for asthma, and concordant non-asthmatic. The transition from initial healthy to immune-system activated physiological states post vaccination will provide unprecedented molecular (omics) data on the molecular dynamics of immune response to vaccination, and novel insight into the flu response. The investigators will infer novel networks and pathways and as well as the dynamics of genes and mechanisms involved in asthma, flu vaccination, and individual responses, and correlate them to evaluated personalized genetic risks in the same study. The investigators will be able to also contrast the vaccination response in asthmatic and non-asthmatic individuals, in a longitudinal approach which has never been performed before using multiple-omics that included an immunization response.
Interventions
- BIOLOGICAL Influenza Vaccination
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2014-10 |
| Est. Completion | 2015-08 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02296359
The ClinicalTrials.gov registry entry for NCT02296359 describes a study currently listed as terminated, categorized as an unspecified phase. The registered enrollment target is 1 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Michigan State University, which has 120 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Influenza Vaccination is the first listed.
NCT02296359 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02296359 about?
NCT02296359 is a clinical study titled "Vaccination Response in Individual Monozygotic Twins". Respiratory viruses are known to be risk factors for asthma (e.g respiratory syncytial viruses, RSVs, and Human Rhinoviruses, HRVs, may induce bronchiolitis, and wheezing illnesses respectively). The common flu is also known to be a risk factor and the Centers for Disease Control and Prevention (CDC...
What is the current status of trial NCT02296359?
This trial is currently terminated. The enrollment target is 1 participants. The study started on 2014-10. Estimated completion is 2015-08.
What interventions are being tested in trial NCT02296359?
The interventions under investigation include: Influenza Vaccination (BIOLOGICAL).
Who is sponsoring clinical trial NCT02296359?
This trial is sponsored by Michigan State University, which has 120 total clinical trials registered on ClinicalTrials.gov.
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