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NCT02281877 · ClinicalTrials.gov registry record · NA
Alterations in Muscle After Total Knee Arthroplasty
A NA study, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT02281877: Completed NA study, sponsored by University of Colorado, Denver.
NCT02281877 is a NA study that has completed, run by University of Colorado, Denver. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02281877, a NA study, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
The overall goals of this work are: 1) to elucidate alterations in gene expression and downstream protein synthesis 2 weeks after Total Knee Arthroplasty (TKA) to better explain quadriceps muscle atrophy after TKA and 2) understand the mechanisms responsible for improved maintenance of muscle strength with Neuromuscular Electrical Stimulation (NMES) utilization. Furthermore, this investigation seeks to expand previous findings regarding attenuation of strength and functional performance deficits with NMES application to better understand how altered gene expression influences muscle function.
Primary Outcome
Standard procedures including total RNA isolation, cDNA synthesis, cRNA labeling, microarray hybridization and image acquisition will be performed. Protein content (translation of MAFbx, MuRF1, myostatin) will be analyzed. Total RNA (500 ng) will be reverse transcribed with the iScript cDNA synthesis kit (Bio-Rad, Hercules, CA), and quantitative PCR will be performed using primer sets for genes of interest, reference genes and iQ SYBR Supermix (Bio-Rad) following manufacturer's protocols.
Interventions
- BEHAVIORAL Standard Rehabilitation Protocol
- PROCEDURE Neuromuscular electrical stimulation (NMES)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2014-10 |
| Est. Completion | 2020-03-09 |
| Phase | NA |
What the finished NCT02281877 record still lists
NCT02281877 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Standard Rehabilitation Protocol is the first listed.
NCT02281877 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02281877 about?
NCT02281877 is a clinical study titled "Alterations in Muscle After Total Knee Arthroplasty". The overall goals of this work are: 1) to elucidate alterations in gene expression and downstream protein synthesis 2 weeks after Total Knee Arthroplasty (TKA) to better explain quadriceps muscle atrophy after TKA and 2) understand the mechanisms responsible for improved maintenance of muscle streng...
What is the current status of trial NCT02281877?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2014-10. Estimated completion is 2020-03-09.
What interventions are being tested in trial NCT02281877?
The interventions under investigation include: Standard Rehabilitation Protocol (BEHAVIORAL), Neuromuscular electrical stimulation (NMES) (PROCEDURE).
Who is sponsoring clinical trial NCT02281877?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02281877's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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