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NCT02278952 · ClinicalTrials.gov registry record
Tacrolimus Adjustment by NFAT-related Gene Expression in Lung Allograft Recipients.
A clinical trial, sponsored by University of California, San Francisco.
- Completed
- Registry status
- 50
- Enrollment target
NCT02278952: Completed study, sponsored by University of California, San Francisco.
NCT02278952 is a clinical trial that has completed, run by University of California, San Francisco. The registered enrollment target is 50 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02278952 has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- 50 participants
- Enrollment target
Study Summary
This is a non-interventional cohort study to assess a novel assay to detect excessive or insufficient immunosuppression from the drug tacrolimus in lung transplant recipients. The assay measures mean residual expression (MRE) of genes downstream of nuclear factor of activated T cells (NFAT), a transcription factor regulated by tacrolimus. The investigators will assess whether MRE levels identify subjects at risk for rejection (insufficient immunosuppression) or infection (excessive immunosuppression).
Primary Outcome
The prescribed tacrolimus dosage was determined by the treating physician who was not aware of the study-assay values. For the study assay, two blood draws were collected at a study visit during the assessment period (from 1 month up to 18 months post-transplant). The first draw occurred before tacrolimus dosage (trough) and the second occurred 90 to 120 minutes after tacrolimus dosage (peak). To determine MRE, whole blood was stimulated, RNA was extracted, and residual expression of NFAT-relate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2014-12 |
| Est. Completion | 2018-01 |
What the finished NCT02278952 record still lists
NCT02278952 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT02278952 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02278952 about?
NCT02278952 is a clinical study titled "Tacrolimus Adjustment by NFAT-related Gene Expression in Lung Allograft Recipients.". This is a non-interventional cohort study to assess a novel assay to detect excessive or insufficient immunosuppression from the drug tacrolimus in lung transplant recipients. The assay measures mean residual expression (MRE) of genes downstream of nuclear factor of activated T cells (NFAT), a trans...
What is the current status of trial NCT02278952?
This trial is currently completed. The enrollment target is 50 participants. The study started on 2014-12. Estimated completion is 2018-01.
Who is sponsoring clinical trial NCT02278952?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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