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NCT02276066 · ClinicalTrials.gov registry record · NA
Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 73
- Enrollment target
NCT02276066: Completed NA study, sponsored by University of Florida.
NCT02276066 is a NA study that has completed, run by University of Florida. The registered enrollment target is 73 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02276066, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 73 participants
- Enrollment target
Study Summary
This study investigates the mechanism by which kidney dysfunction perpetuates inflammation, immunosuppression, and catabolism (PICS) in chronic critical illness. The investigators will test the hypothesis that persistent kidney dysfunction in sepsis associated by chronic critical illness contributes to decreased survival through the development of PICS. In chronic critical illness, the persistence of the inflammatory state may lead to capillary rarefication in the kidney causing accelerated chronic kidney disease. Progression of chronic kidney disease during chronic critical illness can drive PICS. Indeed, many of the features of chronic critical illness are consistent with the protein-energy malnutrition and muscle wasting associated with chronic kidney disease. Thus, the kidney can play a contributory role in chronic critical illness and PICS.
Primary Outcome
The difference between a measured GFR with Iohexol and calculated GFR from creatinine.
Interventions
- DIAGNOSTIC_TEST Urine Collection
- DIAGNOSTIC_TEST GFR by Iohexol
- DIAGNOSTIC_TEST Blood samples
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 73 participants |
| Start Date | 2015-02 |
| Est. Completion | 2023-05-20 |
| Phase | NA |
What the finished NCT02276066 record still lists
NCT02276066 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 73 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 3 interventions - of which Urine Collection is the first listed.
NCT02276066 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02276066 about?
NCT02276066 is a clinical study titled "Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS". This study investigates the mechanism by which kidney dysfunction perpetuates inflammation, immunosuppression, and catabolism (PICS) in chronic critical illness. The investigators will test the hypothesis that persistent kidney dysfunction in sepsis associated by chronic critical illness contributes...
What is the current status of trial NCT02276066?
This trial is currently completed. It is a NA study. The enrollment target is 73 participants. The study started on 2015-02. Estimated completion is 2023-05-20.
What interventions are being tested in trial NCT02276066?
The interventions under investigation include: Urine Collection (DIAGNOSTIC_TEST), GFR by Iohexol (DIAGNOSTIC_TEST), Blood samples (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT02276066?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02276066's enrollment target sits among peer trials
73 1089th of 2000 higher than 912 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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