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NCT02270463 · ClinicalTrials.gov registry record · Phase 1
SL-401 as Consolidation Therapy in Patients With Adverse Risk Acute Myeloid Leukemia in First Complete Remission
A Phase 1 study, sponsored by Stemline Therapeutics.
- Terminated
- Registry status
- Phase 1
- Development phase
- 16
- Enrollment target
NCT02270463: Clinical Trial Phase 1 study, sponsored by Stemline Therapeutics.
NCT02270463 is a Phase 1 study that was terminated before completion, run by Stemline Therapeutics. The registered enrollment target is 16 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02270463, a Phase 1 study, was terminated before completion, sponsored by Stemline Therapeutics.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 16 participants
- Enrollment target
Study Summary
This is a non-randomized, open-label, multicenter, dose escalation study designed to determine the maximum tolerated dose (MTD) of SL-401 in adult patients with acute myeloid leukemia, and to evaluate the safety profile of SL-401 at the MTD.
Primary Outcome
The maximum tolerated dose was defined as the dose preceding the dose level at which 2 or more patients experienced a DLT during treatment Cycle 1.
Interventions
- DRUG Tagraxofusp-erzs
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2015-02 |
| Est. Completion | 2019-12 |
| Phase | Phase 1 |
Why NCT02270463 stopped before completion
NCT02270463 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower).
The record links to 0 conditions, and to 1 intervention - of which Tagraxofusp-erzs is the first listed.
NCT02270463 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02270463 about?
NCT02270463 is a clinical study titled "SL-401 as Consolidation Therapy in Patients With Adverse Risk Acute Myeloid Leukemia in First Complete Remission". This is a non-randomized, open-label, multicenter, dose escalation study designed to determine the maximum tolerated dose (MTD) of SL-401 in adult patients with acute myeloid leukemia, and to evaluate the safety profile of SL-401 at the MTD.
What is the current status of trial NCT02270463?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 16 participants. The study started on 2015-02. Estimated completion is 2019-12.
What interventions are being tested in trial NCT02270463?
The interventions under investigation include: Tagraxofusp-erzs (DRUG).
Who is sponsoring clinical trial NCT02270463?
This trial is sponsored by Stemline Therapeutics, which has 17 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02270463's enrollment target sits among peer trials
16 1786th of 2000 higher than 203 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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