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NCT02267317 · ClinicalTrials.gov registry record · Phase 2
The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects
A Phase 2 study, sponsored by The University of Texas Health Science Center at San Antonio.
- Terminated
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
NCT02267317: Clinical Trial Phase 2 study, sponsored by The University of Texas Health Science Center at San Antonio.
NCT02267317 is a Phase 2 study that was terminated before completion, run by The University of Texas Health Science Center at San Antonio. The registered enrollment target is 15 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02267317, a Phase 2 study, was terminated before completion, sponsored by The University of Texas Health Science Center at San Antonio.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
Study Summary
To determine whether pharmacologic inhibition of Toll-like receptor 4 (TLR4) with eritoran for injection (E5564) will reduce inflammation and improve glucose metabolism in insulin resistant (obese and T2DM) subjects.
Primary Outcome
Muscle insulin sensitivity = muscle insulin sensitivity is determined by euglycemic hyperinsulinemic clamp procedure. M value (mg glucose / kg of body weight / minute) calculated from the clamp is measured. Higher M value indicates better insulin sensitivity. There is no established reference range.
Interventions
- DRUG D5W
- DRUG Eritoran
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2015-01 |
| Est. Completion | 2018-09 |
| Phase | Phase 2 |
Why NCT02267317 stopped before completion
NCT02267317 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 2 interventions - of which D5W is the first listed.
NCT02267317 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02267317 about?
NCT02267317 is a clinical study titled "The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects". To determine whether pharmacologic inhibition of Toll-like receptor 4 (TLR4) with eritoran for injection (E5564) will reduce inflammation and improve glucose metabolism in insulin resistant (obese and T2DM) subjects.
What is the current status of trial NCT02267317?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 2015-01. Estimated completion is 2018-09.
What interventions are being tested in trial NCT02267317?
The interventions under investigation include: D5W (DRUG), Eritoran (DRUG).
Who is sponsoring clinical trial NCT02267317?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 378 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02267317's enrollment target sits among peer trials
15 1919th of 2000 higher than 60 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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