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NCT02239978 · ClinicalTrials.gov registry record
Effect of Levodopa on Postural Motor Learning in Parkinson Disease
A clinical trial, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- 42
- Enrollment target
NCT02239978: Completed study, sponsored by VA Office of Research and Development.
NCT02239978 is a clinical trial that has completed, run by VA Office of Research and Development. The registered enrollment target is 42 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02239978 has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- 42 participants
- Enrollment target
Study Summary
The primary goal of this project is to gain a better understanding of whether and how levodopa (a common anti-Parkinson disease medication) alters postural motor learning in people with Parkinson disease. A secondary goal is to assess whether motor cortical excitability, measured via Transcranial magnetic stimulation, is related to postural motor learning. Participants with Parkinson disease will complete between 50 and 100 postural perturbations (via support surface translations), ON and OFF their dopamine replacement therapy (i.e. levodopa). Adaptation of responses to these perturbations will be tracked. Participants will also undergo transcranial magnetic stimulation to capture cortical excitability of the brain (in particular the motor cortex). Cortical excitability will be correlated to adaptation of stepping (i.e. postural motor learning) ON and OFF levodopa. Investigators will also capture postural motor learning and cortical excitability in age-matched healthy adults. Investigators hypothesize that dopamine will have a negative effect on postural motor learning, and the cortical excitability will be correlated to postural motor learning.
Primary Outcome
Investigators will assess (via automated and custom Matlab software) the magnitude of COM movement after a postural perturbation is delivered via motion of the support surface. This will be measured throughout the intervention, as well as at follow up (24 hour later).
Interventions
- BEHAVIORAL Postural perturbation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2014-08 |
| Est. Completion | 2016-09 |
What the finished NCT02239978 record still lists
NCT02239978 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 42 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Postural perturbation is the first listed.
NCT02239978 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02239978 about?
NCT02239978 is a clinical study titled "Effect of Levodopa on Postural Motor Learning in Parkinson Disease". The primary goal of this project is to gain a better understanding of whether and how levodopa (a common anti-Parkinson disease medication) alters postural motor learning in people with Parkinson disease. A secondary goal is to assess whether motor cortical excitability, measured via Transcranial ma...
What is the current status of trial NCT02239978?
This trial is currently completed. The enrollment target is 42 participants. The study started on 2014-08. Estimated completion is 2016-09.
What interventions are being tested in trial NCT02239978?
The interventions under investigation include: Postural perturbation (BEHAVIORAL).
Who is sponsoring clinical trial NCT02239978?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
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