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COMPLETED Phase 2

Randomized, Placebo Controlled Study Of The Efficacy And Safety Of PF-02545920 In Subjects With Huntington's Disease

NCT02197130 · View on ClinicalTrials.gov ↗

Study Summary

This study is a 26 week, randomized, parallel group, double blind comparison of PF-02545920 5 mg, PF-02545920 20 mg, and placebo dosed BID in the treatment of motor impairment of subjects with Huntington's Disease. A total of approximately 260 subjects are planned to be randomized in the study. Primary endpoint is the change from baseline in the Total Motor Score (TMS) assessment of the Unified Huntington Disease Rating Scale (UHDRS) after 26 weeks of treatment. secondary endpoints will include change from baseline in the Total Maximum Chorea (TMC) score of the UHDRS after 13 and 26 weeks of treatment and Clinical Global Impression-Improvement score after 13 and 26 weeks of treatment.

Conditions Studied

Interventions

  • OTHER Placebo
  • DRUG PF-02545920

Study Locations (20)

California

  • University of California, Irvine — Irvine
  • Ronald Regan UCLA Medical Center Drug Information Center — Los Angeles
  • UCLA Neurology Clinic — Los Angeles
  • UCLA Radiology — Los Angeles

Ohio

  • Cleveland Clinic Foundation Hospital Pharmacy — Cleveland
  • The Cleveland Clinic Foundation — Cleveland
  • Davis Medical Center — Columbus
  • The Wexner Medical Center at the Ohio State University — Columbus

Alabama

  • The Kirklin Clinic of UAB Hospital — Birmingham
  • The University of Alabama at Birmingham — Birmingham
  • University of Alabama at Birmingham — Birmingham

Arizona

  • Mayo Clinic Arizona — Phoenix
  • Mayo Clinic Arizona — Scottsdale

Colorado

  • Rocky Mountain Movement Disorders Center — Englewood

Florida

  • University of Florida Center for Movement Disorders and Neurorestoration — Gainesville

Indiana

  • Indiana University Health Neuroscience Center — Indianapolis

Massachusetts

  • Massachusetts General Hospital — Charlestown

Trial Details

FieldValue
Enrollment Target 272 participants
Start Date 2014-09
Est. Completion 2016-10
Phase Phase 2

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02197130

The ClinicalTrials.gov registry entry for NCT02197130 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 272 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Huntington's Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02197130 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Ohio, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02197130 about?

NCT02197130 is a clinical study titled "Randomized, Placebo Controlled Study Of The Efficacy And Safety Of PF-02545920 In Subjects With Huntington's Disease". This study is a 26 week, randomized, parallel group, double blind comparison of PF-02545920 5 mg, PF-02545920 20 mg, and placebo dosed BID in the treatment of motor impairment of subjects with Huntington's Disease. A total of approximately 260 subjects are planned to be randomized in the study. Prim...

What is the current status of trial NCT02197130?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 272 participants. The study started on 2014-09. Estimated completion is 2016-10.

What conditions does trial NCT02197130 study?

This clinical trial studies the following conditions: Huntington's Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02197130?

The interventions under investigation include: Placebo (OTHER), PF-02545920 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02197130?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02197130 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial