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NCT02176408 · ClinicalTrials.gov registry record · NA
Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major Depression
A NA study, sponsored by Boston University Charles River Campus.
- Completed
- Registry status
- NA
- Development phase
- 38
- Enrollment target
NCT02176408: Completed NA study, sponsored by Boston University Charles River Campus.
NCT02176408 is a NA study that has completed, run by Boston University Charles River Campus. The registered enrollment target is 38 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02176408, a NA study, has completed, sponsored by Boston University Charles River Campus.
- COMPLETED
- Registry status
- NA
- Development phase
- 38 participants
- Enrollment target
Study Summary
Major depressive disorder (MDD) is the leading cause of disability in the developed world and is associated with lost productivity, increased health care utilization, and mortality. Several empirically supported treatments, such as antidepressant medication and cognitive behavioral therapy, exist for the treatment of MDD; however, studies have shown that as many as 34% of individuals do not respond to these treatments. Exercise and stretching interventions represent alternative strategies associated with strong effect sizes in past studies. Additionally, exercise has been shown to enhance cognitive functioning, especially attention and memory. This study aims to investigate the effect of a combined aerobic exercise and behavioral activation treatment (BA) for MDD. Behavioral activation treatment involves completing both pleasant and mastery-based activities with the goal of enhancing mood. The current study will recruit 32 MDD patients for an active treatment phase of nine 60-90 minute sessions (6 weekly sessions and 3 biweekly sessions) of either BA plus exercise (BA+EX) or BA plus stretching (BA+STR). The purpose of this study is to identify if adding aerobic exercise to a brief psychosocial treatment can improve mood above and beyond an active control condition.
Primary Outcome
The MADRS is a 10-item clinician-rated measure of correlates of depression. Specifically, this questionnaire measures the following: sadness, tension, sleep, appetite, concentration, lassitude, numbness, pessimism, and suicidal ideation. The scale ranges from 0-60 with higher totals indicating worse depression. The following are norms for severity: 0 to 6 - normal/symptom absent; 7 to 19 - mild depression; 20 to 34 - moderate depression; and \>34 - severe depression.
Interventions
- BEHAVIORAL Exercise Intervention
- BEHAVIORAL Behavioral Activation
- BEHAVIORAL Stretching Intervention
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 38 participants |
| Start Date | 2014-06 |
| Est. Completion | 2016-08 |
| Phase | NA |
What the finished NCT02176408 record still lists
NCT02176408 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 38 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 3 interventions - of which Exercise Intervention is the first listed.
NCT02176408 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02176408 about?
NCT02176408 is a clinical study titled "Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major Depression". Major depressive disorder (MDD) is the leading cause of disability in the developed world and is associated with lost productivity, increased health care utilization, and mortality. Several empirically supported treatments, such as antidepressant medication and cognitive behavioral therapy, exist fo...
What is the current status of trial NCT02176408?
This trial is currently completed. It is a NA study. The enrollment target is 38 participants. The study started on 2014-06. Estimated completion is 2016-08.
What interventions are being tested in trial NCT02176408?
The interventions under investigation include: Exercise Intervention (BEHAVIORAL), Behavioral Activation (BEHAVIORAL), Stretching Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT02176408?
This trial is sponsored by Boston University Charles River Campus, which has 104 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02176408's enrollment target sits among peer trials
38 1538th of 2000 higher than 461 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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