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NCT02168933 · ClinicalTrials.gov registry record · NA
308nm Excimer Laser for Treatment of Fingernail Psoriasis
A NA study, sponsored by University of Utah.
- Completed
- Registry status
- NA
- Development phase
- 8
- Enrollment target
NCT02168933 is a NA study that has completed, run by University of Utah. The registered enrollment target is 8 participants.
The verdict
NCT02168933, a NA study, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- NA
- Development phase
- 8 participants
- Enrollment target
Study Summary
Psoriasis is a common skin disease, which affects 2-3% of the population. Up to two third of patients with psoriasis develop nail changes. These visible changes can be painful and disabling and are associated with social stigma. Most topical treatments are only partially effective. Systemic treatments can have serious side effects. Excimer laser is a form of targeted ultraviolet light therapy that has been successfully used to treat isolated psoriatic plaques on difficult to treat areas such as scalp or palms. The purpose of this study is to investigate efficacy of excimer laser for treatment of fingernail psoriasis. Sixteen patients with stable fairly symmetric fingernail psoriasis will be enrolled. After obtaining informed consent, an investigator will evaluate the severity of nail psoriasis in each hand using an objective score, called Modified Nail Psoriasis Severity Index (mNAPSI). In a random fashion, one hand will be treated with excimer laser and the other hand will receive sham treatment. During the treatments, patients will wear protective eyewear that does not permit them to see which hand receives active treatment and which hand receives sham treatment. Patients will be treated twice a week for 8 weeks. At weeks 8, 12, and16 the investigator who is blinded to the treatment assignments will re-evaluate the fingernails using mNAPSI score. Mean change from baseline mNAPSI score at weeks 8, 12, and 16 in hands treated with excimer compared to hands treated with sham will be measured. We will also measure patient's assessment of severity of nail disease and the pain or any adverse events associated with laser treatments. Given the slow growth rate of fingernails, the final evaluations will be performed at week 16. In summary, this is the first controlled study to evaluate efficacy of excimer laser in fingernail psoriasis. If found to be effective, excimer laser could be used as a safe, locally administered treatment for recalcitrant nail psoriasis.
Interventions
- DEVICE 308 nm excimer laser
- DEVICE Sham laser
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2014-01 |
| Est. Completion | 2015-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02168933
The ClinicalTrials.gov registry entry for NCT02168933 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 8 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Utah, which has 818 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which 308 nm excimer laser is the first listed.
NCT02168933 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02168933 about?
NCT02168933 is a clinical study titled "308nm Excimer Laser for Treatment of Fingernail Psoriasis". Psoriasis is a common skin disease, which affects 2-3% of the population. Up to two third of patients with psoriasis develop nail changes. These visible changes can be painful and disabling and are associated with social stigma. Most topical treatments are only partially effective. Systemic treatmen...
What is the current status of trial NCT02168933?
This trial is currently completed. It is a NA study. The enrollment target is 8 participants. The study started on 2014-01. Estimated completion is 2015-01.
What interventions are being tested in trial NCT02168933?
The interventions under investigation include: 308 nm excimer laser (DEVICE), Sham laser (DEVICE).
Who is sponsoring clinical trial NCT02168933?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
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