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NCT02159716 · ClinicalTrials.gov registry record · Phase 1
CART-meso in Mesothelin Expressing Cancers
A Phase 1 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 1
- Development phase
- 19
- Enrollment target
NCT02159716: Completed Phase 1 study, sponsored by University of Pennsylvania.
NCT02159716 is a Phase 1 study that has completed, run by University of Pennsylvania. The registered enrollment target is 19 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (68% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02159716, a Phase 1 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 19 participants
- Enrollment target
Study Summary
Phase I study to establish safety and feasibility of intravenously administered lentiviral transduced CART-meso cells administered with and without cyclophosphamide in a 3+3 dose escalation design in patients with metastatic pancreatic cancer, serous epithelial ovarian cancer, or pleural mesothelioma. Dose: 1-3xE7 /mE2 (Cohort 1 and 2) and 1-3xE8 /mE2 (Cohort 3 and 4 ) CAR+ T cells by intravenous route. In the event of 2 DLTs at each dose level, we will dose deescalate by 10-fold.
Interventions
- BIOLOGICAL CART-meso
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2014-06 |
| Est. Completion | 2015-11 |
| Phase | Phase 1 |
What the finished NCT02159716 record still lists
NCT02159716 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 19 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (68% lower).
The record links to 0 conditions, and to 1 intervention - of which CART-meso is the first listed.
NCT02159716 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02159716 about?
NCT02159716 is a clinical study titled "CART-meso in Mesothelin Expressing Cancers". Phase I study to establish safety and feasibility of intravenously administered lentiviral transduced CART-meso cells administered with and without cyclophosphamide in a 3+3 dose escalation design in patients with metastatic pancreatic cancer, serous epithelial ovarian cancer, or pleural mesotheliom...
What is the current status of trial NCT02159716?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 19 participants. The study started on 2014-06. Estimated completion is 2015-11.
What interventions are being tested in trial NCT02159716?
The interventions under investigation include: CART-meso (BIOLOGICAL).
Who is sponsoring clinical trial NCT02159716?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02159716's enrollment target sits among peer trials
19 1716th of 2000 higher than 281 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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