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NCT02157844 · ClinicalTrials.gov registry record
Fat Metabolism in OSA and COPD
A clinical trial, sponsored by Texas A&M University.
- Completed
- Registry status
- 62
- Enrollment target
NCT02157844: Completed study, sponsored by Texas A&M University.
NCT02157844 is a clinical trial that has completed, run by Texas A&M University. The registered enrollment target is 62 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02157844 has completed, sponsored by Texas A&M University.
- COMPLETED
- Registry status
- 62 participants
- Enrollment target
Study Summary
Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by an obstruction of the upper airways. The obstruction results in periods of intermittent hypoxia and re-oxygenation, which lead to increased oxidative stress, increased inflammation, endothelial dysfunction, and insulin resistance. Chronic obstructive pulmonary disease (COPD) is a lung disease that leads to poor airflow. This disease leads to systemic hypoxia, reduced oxidative capacity, and increased inflammation. The direct cause of OSA and COPD is unclear, but OSA and COPD may be linked to other comorbid conditions such as obesity and type II diabetes. Upon onset of OSA and COPD, metabolic disturbances associated with obesity and type II diabetes can be exacerbated. Obesity is a condition characterized by an increase in visceral fat, elevated plasma levels of free fatty acids, inflammation, and insulin resistance. Although the effects of body fat distribution have not been studied in these patients, an increase in both subcutaneous and abdominal fat mass in non-OSA older women was shown to increase morbidity and mortality. Fat/adipose tissue is an active tissue capable of secreting proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, reactive oxygen species and adipokines. Particularly, abdominal fat is a prominent source of pro-inflammatory cytokines, which contributes to a low grade, chronic inflammatory state in these patients. Additionally, an increased inflammatory state is associated with reduced lean body mass, and together with elevated circulating free fatty acids may increase the occurrence of lipotoxicity and insulin resistance. Thus, increased fat deposition is associated with a poor prognosis in OSA and COPD patients and therefore it is of clinical and scientific importance to understand the changes in fat metabolism and digestion as a result of OSA and COPD. It is therefore our hypothesis that fat synthesis and insulin resist
Primary Outcome
changes in hepatic triglyceride synthesis before and after a meal
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2014-04 |
| Est. Completion | 2017-12 |
What the finished NCT02157844 record still lists
NCT02157844 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 62 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT02157844 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02157844 about?
NCT02157844 is a clinical study titled "Fat Metabolism in OSA and COPD". Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by an obstruction of the upper airways. The obstruction results in periods of intermittent hypoxia and re-oxygenation, which lead to increased oxidative stress, increased inflammation, endothelial dysfunction, and ins...
What is the current status of trial NCT02157844?
This trial is currently completed. The enrollment target is 62 participants. The study started on 2014-04. Estimated completion is 2017-12.
Who is sponsoring clinical trial NCT02157844?
This trial is sponsored by Texas A&M University, which has 95 total clinical trials registered on ClinicalTrials.gov.
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