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NCT02154685 · ClinicalTrials.gov registry record · NA
Extinction Updating in Reconsolidation
A NA study, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- NA
- Development phase
- 77
- Enrollment target
NCT02154685: Completed NA study, sponsored by Medical University of South Carolina.
NCT02154685 is a NA study that has completed, run by Medical University of South Carolina. The registered enrollment target is 77 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02154685, a NA study, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- NA
- Development phase
- 77 participants
- Enrollment target
Study Summary
Smoking occurs in approximately 21% of the US population, is responsible for an annual mortality rate of approximately 438,000 citizens, and has an associated healthcare economic burden of $167 billion. Although pharmacotherapies have improved cessation outcome, the vast majority of individuals making quit attempts relapse within 5-10 days of cessation. The hypotheses to be examined in this study may have potentially important implications for smoking cessation treatment and will, therefore, target the single greatest addiction-related cause of morbidity and mortality.This study will investigate a novel behavioral strategy for altering important memory processes that underlie human smoking-related nicotine addiction. This strategy used in this study employs established cue exposure procedures to putatively update smoking-related memory with information that will suppress responding to smoking cues. The goal here is to alter existing nicotine-related memory directly rather than rely exclusively on the establishment of an inhibitory extinction process, via traditional cue exposure therapy, which is known to be vulnerable to spontaneous recovery, renewal and reinstatement. Positive findings would represent a significant advance in exposure-based therapy for addiction and could lead to a treatment that uniquely targets the problem of cue-elicited craving and reactivity, thereby addressing a major obstacle to successful smoking cessation.
Primary Outcome
A craving questionnaire and mood form is given to participants to complete at several time points throughout the visit to access nicotine craving.
Interventions
- BEHAVIORAL Retrieval-Extinction
- BEHAVIORAL Non-Retrieval Extinction
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 77 participants |
| Start Date | 2013-12 |
| Est. Completion | 2015-09 |
| Phase | NA |
What the finished NCT02154685 record still lists
NCT02154685 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 77 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Retrieval-Extinction is the first listed.
NCT02154685 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02154685 about?
NCT02154685 is a clinical study titled "Extinction Updating in Reconsolidation". Smoking occurs in approximately 21% of the US population, is responsible for an annual mortality rate of approximately 438,000 citizens, and has an associated healthcare economic burden of $167 billion. Although pharmacotherapies have improved cessation outcome, the vast majority of individuals maki...
What is the current status of trial NCT02154685?
This trial is currently completed. It is a NA study. The enrollment target is 77 participants. The study started on 2013-12. Estimated completion is 2015-09.
What interventions are being tested in trial NCT02154685?
The interventions under investigation include: Retrieval-Extinction (BEHAVIORAL), Non-Retrieval Extinction (BEHAVIORAL).
Who is sponsoring clinical trial NCT02154685?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02154685's enrollment target sits among peer trials
77 1062nd of 2000 higher than 939 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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