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NCT02151552 · ClinicalTrials.gov registry record · Early Phase 1
Assessing NOS Uptake With PET Imaging in Lung Inflammation
A Early Phase 1 study, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 3
- Enrollment target
NCT02151552: Completed Early Phase 1 study, sponsored by Washington University School of Medicine.
NCT02151552 is a Early Phase 1 study that has completed, run by Washington University School of Medicine. The registered enrollment target is 3 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02151552, a Early Phase 1 study, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 3 participants
- Enrollment target
Study Summary
The purpose of this study is to learn more about the basic responses of the lungs to inflammation using positron emission tomography, or PET, imaging scans of the lungs. PET is a machine that detects radiation and generates pictures using a donut-shaped scanner similar in appearance to an x-ray "CAT" or computed tomography (CT) scan or an MRI. Inflammation is the way our bodies react to irritation or injury, and involves red, warm, and often painful swelling of the affected tissue. An enzyme called inducible nitric oxide synthase (iNOS) contributes to the development of lung inflammation.
Primary Outcome
Comparison of DVR by Logan plot for \[18F\](+/-)NOS uptake, pulmonary blood flow (PBF) and extravascular lung water (EVLW) in the regions of interest generated from scans obtained before and after endotoxin instillation and in the right and left lungs will be compared using a repeated-measures t-test, with statistical significance set at p\<0.05. The DVR determined for \[18F\](+/-)NOS normalized for either PBF or EVLW will also be compared using a repeated-measures t-test before and after endoto
Interventions
- DRUG Endotoxin (E. coli O:113, Reference Endotoxin)
- DRUG [18F](+/-)NOS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2014-05 |
| Est. Completion | 2018-02 |
| Phase | Early Phase 1 |
What the finished NCT02151552 record still lists
NCT02151552 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 2 interventions - of which Endotoxin (E. coli O:113, Reference Endotoxin) is the first listed.
NCT02151552 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02151552 about?
NCT02151552 is a clinical study titled "Assessing NOS Uptake With PET Imaging in Lung Inflammation". The purpose of this study is to learn more about the basic responses of the lungs to inflammation using positron emission tomography, or PET, imaging scans of the lungs. PET is a machine that detects radiation and generates pictures using a donut-shaped scanner similar in appearance to an x-ray "CAT...
What is the current status of trial NCT02151552?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 3 participants. The study started on 2014-05. Estimated completion is 2018-02.
What interventions are being tested in trial NCT02151552?
The interventions under investigation include: Endotoxin (E. coli O:113, Reference Endotoxin) (DRUG), [18F](+/-)NOS (DRUG).
Who is sponsoring clinical trial NCT02151552?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02151552's enrollment target sits among peer trials
3 1949th of 2000 higher than 28 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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