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NCT02141555 · ClinicalTrials.gov registry record · Phase 2
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
A Phase 2 study, sponsored by University of California, San Diego.
- Completed
- Registry status
- Phase 2
- Development phase
- 4
- Enrollment target
NCT02141555: Completed Phase 2 study, sponsored by University of California, San Diego.
NCT02141555 is a Phase 2 study that has completed, run by University of California, San Diego. The registered enrollment target is 4 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02141555, a Phase 2 study, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 4 participants
- Enrollment target
Study Summary
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion. There are several ways in which missed abortions are managed, one of which involves administering a medication called misoprostol which causes uterine contractions inducing expulsion of the failed pregnancy. Misoprostol can be administered in multiple ways but has been traditionally inserted vaginally when used for management of missed abortions. Some studies have shown that some women are not comfortable with vaginal insertion of misoprostol and prefer oral administration. Buccal misoprostol is a way of administering misoprostol by having the patients insert the tablets of misoprostol between their gum and cheek, letting it dissolve for 30 minutes, then swallowing the remaining remnants. Buccal misoprostol is used safely in medical abortion. In fact a study by Fjerstad et al (2009), found a decrease in infection rate for medical abortion when misoprostol administration was switched from vaginal to buccal route combined with routine administration of doxycycline. The efficacy of using buccal misoprostol to treat missed abortions has not been studied previously to the investigators' knowledge. In this pilot study, investigators aim to test the hypotheses that buccal misoprostol is equally effective as vaginal misoprostol in the medical management of early pregnancy loss. As secondary outcomes, investigators suspect that buccal misoprostol may be associated with higher rates of gastrointestinal side effect but that patient satisfaction will remain equally as high for buccal misoprostol as for vaginal misoprostol.
Primary Outcome
The percentage of women who are offered enrollment and accept.
Interventions
- DRUG Vaginal Misoprostol
- DRUG Buccal Misoprostol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2014-08 |
| Est. Completion | 2016-06 |
| Phase | Phase 2 |
What the finished NCT02141555 record still lists
NCT02141555 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Vaginal Misoprostol is the first listed.
NCT02141555 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02141555 about?
NCT02141555 is a clinical study titled "Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss". First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion. There are several ways in which missed abortions are managed, one of which involves administering a medication called misoprostol which causes uterine contractio...
What is the current status of trial NCT02141555?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 4 participants. The study started on 2014-08. Estimated completion is 2016-06.
What interventions are being tested in trial NCT02141555?
The interventions under investigation include: Vaginal Misoprostol (DRUG), Buccal Misoprostol (DRUG).
Who is sponsoring clinical trial NCT02141555?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02141555's enrollment target sits among peer trials
4 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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