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NCT02135406 · ClinicalTrials.gov registry record · Phase 1
CART-19 for Multiple Myeloma
A Phase 1 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 1
- Development phase
- 13
- Enrollment target
NCT02135406: Completed Phase 1 study, sponsored by University of Pennsylvania.
NCT02135406 is a Phase 1 study that has completed, run by University of Pennsylvania. The registered enrollment target is 13 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02135406, a Phase 1 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 13 participants
- Enrollment target
Study Summary
The primary goals: determine the safety, tolerability and engraftment potential of CART-19 T cells in patients undergoing salvage ASCT after early relapse following first ASCT. CART-19 cells transduced with a lentiviral vector to express anti-CD19 scFv TCR(zeta):41BB administered by intravenous infusion using a single infusion of 1-5x108 CART19-transduced T cells on day +2 after autologous stem cell infusion following high-dose melphalan.
Interventions
- BIOLOGICAL CART-19 T cells
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2014-05 |
| Est. Completion | 2018-01-18 |
| Phase | Phase 1 |
What the finished NCT02135406 record still lists
NCT02135406 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower).
The record links to 0 conditions, and to 1 intervention - of which CART-19 T cells is the first listed.
NCT02135406 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02135406 about?
NCT02135406 is a clinical study titled "CART-19 for Multiple Myeloma". The primary goals: determine the safety, tolerability and engraftment potential of CART-19 T cells in patients undergoing salvage ASCT after early relapse following first ASCT. CART-19 cells transduced with a lentiviral vector to express anti-CD19 scFv TCR(zeta):41BB administered by intravenous infu...
What is the current status of trial NCT02135406?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2014-05. Estimated completion is 2018-01-18.
What interventions are being tested in trial NCT02135406?
The interventions under investigation include: CART-19 T cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT02135406?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02135406's enrollment target sits among peer trials
13 1847th of 2000 higher than 149 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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