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NCT02133898 · ClinicalTrials.gov registry record · NA
The Use Of L-Methylfolate As A Treatment For Depression
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 57
- Enrollment target
NCT02133898: Completed NA study, sponsored by University of Florida.
NCT02133898 is a NA study that has completed, run by University of Florida. The registered enrollment target is 57 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02133898, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 57 participants
- Enrollment target
Study Summary
This is an open-label study assessing the efficacy of l-methylfolate as monotherapy in patients with mild to moderate major depressive disorder (MDD). The plan is to enroll 75 patients with mild to moderate MDD based on the Structured Clinical Interview for DSM-IV (SCID) that have a Hamilton Depression Rating Scale-24 (HDRS-24) score between 8-24. The investigators will collect genotype data on methylenetetrahydrofolate Reductase (MTHFR), MTR and MTRR in this patient population. Subjects will be able to receive their genotype results, on request, upon completion of the study. The investigators hypothesize that depressed patients will be more likely to have a mutation in the MTHFR gene
Primary Outcome
Clinician-administered questionnaire designed to assess the severity of depression in adults. It has been considered the gold standard for rating depression in clinical research.
Interventions
- OTHER L-methylfolate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 57 participants |
| Start Date | 2016-02 |
| Est. Completion | 2023-04-04 |
| Phase | NA |
What the finished NCT02133898 record still lists
NCT02133898 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 57 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which L-methylfolate is the first listed.
NCT02133898 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02133898 about?
NCT02133898 is a clinical study titled "The Use Of L-Methylfolate As A Treatment For Depression". This is an open-label study assessing the efficacy of l-methylfolate as monotherapy in patients with mild to moderate major depressive disorder (MDD). The plan is to enroll 75 patients with mild to moderate MDD based on the Structured Clinical Interview for DSM-IV (SCID) that have a Hamilton Depress...
What is the current status of trial NCT02133898?
This trial is currently completed. It is a NA study. The enrollment target is 57 participants. The study started on 2016-02. Estimated completion is 2023-04-04.
What interventions are being tested in trial NCT02133898?
The interventions under investigation include: L-methylfolate (OTHER).
Who is sponsoring clinical trial NCT02133898?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02133898's enrollment target sits among peer trials
57 1261st of 2000 higher than 739 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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