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NCT02133586 · ClinicalTrials.gov registry record · NA
Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers.
A NA study, sponsored by Environmental Protection Agency (EPA).
- Completed
- Registry status
- NA
- Development phase
- 54
- Enrollment target
NCT02133586: Completed NA study, sponsored by Environmental Protection Agency (EPA).
NCT02133586 is a NA study that has completed, run by Environmental Protection Agency (EPA). The registered enrollment target is 54 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02133586, a NA study, has completed, sponsored by Environmental Protection Agency (EPA).
- COMPLETED
- Registry status
- NA
- Development phase
- 54 participants
- Enrollment target
Study Summary
The U.S. Environmental Protection Agency has traditionally examined the effects of single pollutant exposure on human health outcomes; however, to provide a better assessment of pollutant exposure-associated effect on human health the Agency is moving toward a multi-pollutant approach. Ozone (O3) and nitrogen dioxide (NO2) are national ambient air quality standards (NAAQS) criteria pollutants that are major constituents of ambient air pollution. This study will address the Agency's goals by investigating the cardiopulmonary health effects of sequential exposure to O3 and NO2 in healthy adult human volunteers. The findings of this study will provide data that will inform risk assessment models for O3 and NO2 exposures. Additionally, the findings will provide insight into how the human health effects of multi-pollutant exposures differ from those of single pollutant exposures.
Primary Outcome
Measurements are taken pre-exposure ("baseline" measurement), immediately post-exposure, and 24 hours post-exposure. Changes in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) will be assessed as indicators of change in pulmonary function.
Interventions
- OTHER Ozone
- OTHER Nitrogen dioxide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2014-01 |
| Est. Completion | 2016-01 |
| Phase | NA |
What the finished NCT02133586 record still lists
NCT02133586 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 54 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Ozone is the first listed.
NCT02133586 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02133586 about?
NCT02133586 is a clinical study titled "Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers.". The U.S. Environmental Protection Agency has traditionally examined the effects of single pollutant exposure on human health outcomes; however, to provide a better assessment of pollutant exposure-associated effect on human health the Agency is moving toward a multi-pollutant approach. Ozone (O3) an...
What is the current status of trial NCT02133586?
This trial is currently completed. It is a NA study. The enrollment target is 54 participants. The study started on 2014-01. Estimated completion is 2016-01.
What interventions are being tested in trial NCT02133586?
The interventions under investigation include: Ozone (OTHER), Nitrogen dioxide (OTHER).
Who is sponsoring clinical trial NCT02133586?
This trial is sponsored by Environmental Protection Agency (EPA), which has 9 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02133586's enrollment target sits among peer trials
54 1268th of 2000 higher than 730 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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