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NCT02120339 · ClinicalTrials.gov registry record · Phase 1
Carvedilol PAH A Pilot Study of Efficacy and Safety
A Phase 1 study, sponsored by University of Minnesota.
- Terminated
- Registry status
- Phase 1
- Development phase
- 5
- Enrollment target
NCT02120339: Clinical Trial Phase 1 study, sponsored by University of Minnesota.
NCT02120339 is a Phase 1 study that was terminated before completion, run by University of Minnesota. The registered enrollment target is 5 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02120339, a Phase 1 study, was terminated before completion, sponsored by University of Minnesota.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
Estimate the effect of chronic beta-adrenergic receptor blockade with carvedilol on RV function in patients with PAH. Assess the safety and tolerability of chronic carvedilol therapy in patients with PAH
Primary Outcome
1\. The primary efficacy outcome is the mean change in RVEF as measured by cardiac MRI before and after 6 months of carvedilol treatment. An improvement of 5% will be considered to be clinically significant. Assessment of the RV is challenging due to its complex geometry. Cardiac MRI offers the ability to acquire 3-dimensional datasets that do not require geometric modeling. In addition to being highly reproducible40, RVEF measured by cardiac MRI can be used to identify PAH patients that are lik
Interventions
- DRUG Carvedilol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2014-05 |
| Est. Completion | 2016-06 |
| Phase | Phase 1 |
Why NCT02120339 stopped before completion
NCT02120339 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 1 intervention - of which Carvedilol is the first listed.
NCT02120339 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02120339 about?
NCT02120339 is a clinical study titled "Carvedilol PAH A Pilot Study of Efficacy and Safety". Estimate the effect of chronic beta-adrenergic receptor blockade with carvedilol on RV function in patients with PAH. Assess the safety and tolerability of chronic carvedilol therapy in patients with PAH
What is the current status of trial NCT02120339?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 5 participants. The study started on 2014-05. Estimated completion is 2016-06.
What interventions are being tested in trial NCT02120339?
The interventions under investigation include: Carvedilol (DRUG).
Who is sponsoring clinical trial NCT02120339?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02120339's enrollment target sits among peer trials
5 1989th of 2000 higher than 6 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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